“…The mechanisms underlying the reprogramming process are not well understood yet; however the three main transcription factors Oct4, Sox2 and Nanog, called master regulators of pluripotency, have proved responsible for maintaining the undifferentiated state. Basically both processes, reprograming and transformation, need the expression or activation of oncogenes (expression of Oct4, Sox2 and Nanog has been repeatedly observed in tumors), inactivation of tumor suppressor genes, overriding the senescence and apoptotic barriers and both processes also involve epigenetic changes and a metabolic switch towards a glycolytic metabolism [3,4]. The tumor suppressor p53 poses a barrier for pluripotency induction [5].…”