Induced Premaxillary Suture Fusion: Class III Malocclusion Model

Ruan, Wen-hua; Winger, Julia N.; Yu, Jack C.; Borke, James L.

doi:10.1177/154405910808700901

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…A biomechanical relationship between cranial sutures and mastication has also been proven in experimental animals. In rats, artificial fusion of a suture can lead to malocclusion, and malocclusion can lead to suture remodelling (Kasahara 2000;Ruan et al 2008). In the present case, multiple suture exostoses were found concurrent to a nasal septum chondrosarcoma.…”

Section: Discussionsupporting

confidence: 46%

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Suture exostosis with concurrent nasal septum chondrosarcoma in a horse

Bonilla

Wilson

Santschi

2015

Equine Veterinary Education

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A 15-year-old Hanoverian mare presented with a 10-day history of facial swelling in the right maxillary and frontal regions, left epiphora and intermittent right epistaxis. Radiographs revealed suture exostosis of both nasofrontal sutures and a deviated and thickened nasal septum. Computed tomography (CT) of the skull revealed exostosis of the nasolacrimal sutures and ducts bilaterally of both nasofrontal sutures and of the right zygomatocomaxillary and lacrimomaxillary sutures. The mid-to-caudal aspect of the nasal septum was thickened and had multiple well demarcated hypoattenuated regions within the septum. Histological examination of biopsies taken from the right nasofrontal suture and the nasal septal mass revealed suture exostosis and nasal septum chondrosarcoma. The horse was treated with rest and anti-inflammatories. The facial swelling and left epiphora were improved at 7 months telephone follow-up. This report is the first to describe a nasal septum chondrosarcoma in a horse. Additionally, we suggest that the suture exostosis may have developed due to an alteration of the biomechanics of the skull sutures secondary to the septal tumour.

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Section: Discussionsupporting

confidence: 46%

“…In rats, artificial fusion of a suture can lead to malocclusion, and malocclusion can lead to suture remodelling (Kasahara ; Ruan et al . ). In the present case, multiple suture exostoses were found concurrent to a nasal septum chondrosarcoma.…”

Section: Discussionmentioning

confidence: 97%

Suture exostosis with concurrent nasal septum chondrosarcoma in a horse

Bonilla

Wilson

Santschi

2015

Equine Veterinary Education

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“…As previously mentioned, Class III malocclusion may result from maxillary retrognathism and/or mandibular overgrowth, and both FGFR2 and FGFR3 may be related to maxillary retrognathism and/or hypoplasia, as evidenced by their involvement in cranial suture biology and craniosynostosis. Induced premaxillary suture fusion has been shown to affect craniofacial morphology, and implies that abnormal premaxillary suture function may result in Class III malocclusion (Ruan et al ., 2008). Moreover, constitutive gain-of-function mutations within FGFR1 and FGFR2 , and dominant-negative mutation of FGFR3 , are causing strikingly different phenotypes, all of which are involving craniosynostosis as a distinctive feature of an underlying syndrome (Wilkie, 2005).…”

Section: Discussionmentioning

confidence: 99%

A Missense Mutation in DUSP6 is Associated with Class III Malocclusion

et al. 2013

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Class III malocclusion is a common dentofacial phenotype with a variable prevalence according to ethnic background. The etiology of Class III malocclusion has been attributed mainly to interactions between susceptibility genes and environmental factors during the morphogenesis of the mandible and maxilla. Class III malocclusion shows familial recurrence, and family-based studies support a predominance of an autosomal-dominant mode of inheritance. We performed whole-exome sequencing on five siblings from an Estonian family affected by Class III malocclusion. We identified a rare heterozygous missense mutation, c.545C>T (p.Ser182Phe), in the DUSP6 gene, a likely causal variant. This variant co-segregated with the disease following an autosomal-dominant mode of inheritance with incomplete penetrance. Transcriptional activation of DUSP6 has been presumed to be regulated by FGF/FGFR and MAPK/ERK signaling during fundamental processes at early stages of skeletal development. Several candidate genes within a linkage region on chromosome 12q22-q23--harboring DUSP6--are implicated in the regulation of maxillary or mandibular growth. The current study reinforces that the 12q22-q23 region is biologically relevant to craniofacial development and may be genetically linked to the Class III malocclusion.

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“…As previously revealed, class III malocclusion is may the consequence of mandibular prognathism and/ or maxillary retrognathism 36) mentioned that FGFR2 and FGFR3 might be allied to maxillary retrognathism as showed by their contribution in cranial suture biology and craniosynostosis that may be the outcome of class III malocclusion due to abnormal premaxillary suture function.…”

Section: Discussionmentioning

confidence: 98%

Craniofacial Morphology of Class III Malocclusion with DUSP6 Gene: Mutation and Non-Mutation Groups

Nowrin

Alam

Yusa

et al. 2016

J. Hard Tissue Biology.

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Abstact: The etiology of developing class III malocclusion and the role of craniofacial structures in this phenotype remain indistinct. The purpose of this study was to compare the relative relationship of craniofacial structures of DUSP6 gene mutation and non-mutation groups in class III malocclusion of Malaysian Malay families and their three generations. Thirty class III cephalometric radiographs of ten Malaysian Malay families including three generations with an average age 23, 54 and 79 years of each generation respectively were studied. All landmarks were positioned, determined and consequently tracings were completed Romexis software (Planmeca, Finland) to accomplish craniofacial morphology investigation. The statistical comparisons of the mutation and non-mutation group were conducted with independent t test and analysis of variance (ANOVA) was applied to evaluate the values for three generations in class III malocclusion among all measurements. The result of the current study revealed that in mutation group, there are significant differences in Co-Gn-B and SN-MDP variables compare to non-mutation group. However, almost all craniofacial variables show no significant differences among three generations. This study may suggest that in mutation group mandible is more deviated from cranial base compare to non-mutation group and there are virtually no skeletal changes among three generations with age in case of growing class III malocclusion.

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Induced Premaxillary Suture Fusion: Class III Malocclusion Model

Cited by 6 publications

References 18 publications

Suture exostosis with concurrent nasal septum chondrosarcoma in a horse

Suture exostosis with concurrent nasal septum chondrosarcoma in a horse

A Missense Mutation in DUSP6 is Associated with Class III Malocclusion

Craniofacial Morphology of Class III Malocclusion with DUSP6 Gene: Mutation and Non-Mutation Groups

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