Induced Production of Bromomethylchlamydosporols A and B from the Marine-Derived Fungus <i>Fusarium tricinctum</i>

Nenkep, Viviane N.; Yun, Keumja; Zhang, Dahai; Choi, Hong Dae; Kang, Jung Sook; Son, Byeng Wha

doi:10.1021/np1005289

Cited by 32 publications

(23 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fermentation conditions of the potential fungal strain significantly affect the secondary metabolism of marine fungi. Some of the new antimicrobial compounds from marine fungi are only produced under high salinity [ 33 , 48 , 66 ]. The fungal strains that new antimicrobial compounds have been isolated from are recommended for investigation of their metabolic changes under different fermentation processes (especially under high salinity).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial and Antifungal Compounds from Marine Fungi

et al. 2015

View full text Add to dashboard Cite

This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The addition of CaBr 2 to the fermentation media resulted in the production of two halogenated chlamydosporol analogs, 75 and 76 . Compounds 75 and 76 showed the same activity against three strains of S. aureus (MIC, 15.6 µg/mL) [ 66 ].…”

Section: New Antibacterial and Antifungal Compounds From Marine Fumentioning

confidence: 99%

Antibacterial and Antifungal Compounds from Marine Fungi

et al. 2015

View full text Add to dashboard Cite

show abstract

“…3) From the surface of the edible green algae, Codium fragile (Korean name: CheongGak), we have isolated a fungal strain Aspergillus flavus. When cultivated under saline conditions, the broth and mycelium of a 1 l cultivation of A. flavus were found to exhibit mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus.…”

mentioning

confidence: 99%

Flavusides A and B, Antibacterial Cerebrosides from the Marine-Derived Fungus Aspergillus flavus

et al. 2011

Self Cite

View full text Add to dashboard Cite

Marine microorganisms, particularly marine fungi, have recently gained prominence as an important source of biologically active secondary metabolites.1) Among the marine fungi, those living in association with marine algae are a particularly promising source of novel natural products due to the special ecological niche in which they exist.2) As part of a program to explore the bioactive metabolites produced by fungi isolated from marine habitats, our efforts have focused on microorganisms found in association with edible seaweed.3) From the surface of the edible green algae, Codium fragile (Korean name: CheongGak), we have isolated a fungal strain Aspergillus flavus. When cultivated under saline conditions, the broth and mycelium of a 1 l cultivation of A. flavus were found to exhibit mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. This paper describes the isolation and structure elucidation of two antibacterial cerebrosides, flavusides A (1) and B (2), and identification of four known phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6). C-NMR spectra of 1, including spectra from distortionless enhancement by polarization transfer (DEPT), correlation spectroscopy (COSY), heteronuclear multiple quantum correlation (HMQC), and heteronuclear multiple bond coherence (HMBC) experiments, revealed signals that were ascribable to a monosaccharide (an anomeric proton at d H 4.11), an amide linkage (a nitrogenated methine proton at d H 3.81 and a carbonyl carbon at d C 173.7), and an aliphatic long chain (terminal methyl protons at d H 0.85 and methylene protons at d H 1.22-1.43), indicating that the compound was a glycosphingolipid. The 6) The absolute configuration of the glucose moiety was found to be D (vide infra). Seoul 130-701, Korea. Received April 15, 2011; accepted June 7, 2011; published online June 8, 2011 Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 m mg/ml for S. aureus and 31.2 m mg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 m mg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 m mg/ml for multidrug-resistant S. aureus.

show abstract

“…The fungi inhabiting or associated with marine algae defined marine algicolous fungi have attracted a great attention for natural product researchers during the past two decades. At least 400 new secondary metabolites have been isolated from them up to now, including Aspergillus, Penicillium, Fusarium and Trichoderma (Nenkep et al 2010;Sun et al 2012;Tsuda et al 2004). It has been discovered that Trichoderma fungi are almost ubiquitous in terrestrial and aquatic environments.…”

Section: Introductionmentioning

confidence: 99%

Three nitrogen-containing metabolites from an algicolous isolate of Trichoderma asperellum

Song

Miao

Yin

et al. 2020

Mar Life Sci Technol

View full text Add to dashboard Cite

As one of the most productive species, Trichoderma asperellum, especially isolated from marine algae, has contributed a number of new terpenes and nitrogen-bearing compounds, encouraging our continuous efforts to further explore them. Consequently, three new nitrogen-containing secondary metabolites, including cyclo(L-5-MeO-Pro-L-5-MeO-Pro) (1), 5′-acetoxy-deoxycyclonerin B (2), and 5′-acetoxy-deoxycyclonerin D (3) were isolated from the marine alga-derived endophytic fungus Trichoderma asperellum A-YMD-9-2. Their structures and relative configurations were fully elucidated through spectroscopic techniques, mainly including 1D/2D NMR and MS. The absolute configurations of 1 and 2 were ascertained on the basis of X-ray diffraction (Cu Kα radiation) and ECD data, respectively. The isolation of these new nitrogen-bearing compounds adds to the structural diversity of marine algicolous Trichoderma spp., and they display potent inhibition against some marine phytoplankton species.

show abstract

Induced Production of Bromomethylchlamydosporols A and B from the Marine-Derived Fungus Fusarium tricinctum

Cited by 32 publications

References 16 publications

Antibacterial and Antifungal Compounds from Marine Fungi

Antibacterial and Antifungal Compounds from Marine Fungi

Flavusides A and B, Antibacterial Cerebrosides from the Marine-Derived Fungus Aspergillus flavus

Three nitrogen-containing metabolites from an algicolous isolate of Trichoderma asperellum

Contact Info

Product

Resources

About