Induced protein degradation for therapeutics: past, present, and future

Molecular Glues & Bifunctional Compounds: Therapeutic Modalities Based on Induced Proximity

“…46 The illumination of the molecular mechanism-of-action of the simple myeloma drug lenalidomide/Revlimid and its structural analogs such as thalidomide further reinforced this notion. 47 Undrugged protein targets. In the 1980s, both phosphatases and kinases were in the "undrugged" category, which today of course is hard to imagine given the plethora of protein kinase-targeting drugs.…”