Inducement of tissue regeneration of harvested hamstring tendons in a rabbit model

Tabuchi, Kousuke; Soejima, T.; Murakami, Hidetaka; Noguchi, Kevin K.; Shiba, Naoto; Nagata, Kensei

doi:10.1302/2046-3758.56.2000585

Cited by 3 publications

(5 citation statements)

References 15 publications

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“…Neither previous studies report distal ST insertion changes within a tibial coordinate system (e.g., proximal/distal, anterior/posterior dimensions), nor is it clear what explains the conflicting results across studies. Indeed, the mechanism of distal ST tendon regeneration has not been clearly identified but is hypothesized to be aided by medial layers of fascia enveloping ST which might provide a tubular sheath and pathway to reinsertion 44,45 . If so, preservation of fascial sheath or augmentation of harvesting procedure with the addition of a inducer graft 45 may improve future tendon regeneration outcomes for hamstring autografts.…”

Section: Discussionmentioning

confidence: 99%

“…reported recently by Nikose et al, 42 hypothesized to be aided by medial layers of fascia enveloping ST which might provide a tubular sheath and pathway to reinsertion. 44,45 If so, preservation of fascial sheath or augmentation of harvesting procedure with the addition of a inducer graft 45 may improve future tendon regeneration outcomes for hamstring autografts.…”

Section: Joint Torque Analysismentioning

confidence: 99%

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Moment arm and torque generating capacity of semitendinosus following tendon harvesting for anterior cruciate ligament reconstruction: A simulation study

du Moulin,

Bourne,

Diamond

et al. 2024

Journal Orthopaedic Research

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Altered semitendinosus (ST) morphology and distal tendon insertion following anterior cruciate ligament reconstruction (ACLR) may reduce knee flexion torque generating capacity of the hamstrings via impaired ST force generation and/or moment arm. This study used a computational musculoskeletal model to simulate mechanical consequences of tendon harvest for ACLR on ST function by modeling changes in ST muscle tendon insertion point, moment arm, and torque generating capacity across a physiological range of motion. Simulated ST function was then compared between ACLR and uninjured contralateral limbs. Magnetic resonance imaging from 18 individuals with unilateral history of ACLR involving a hamstring autograft was used to analyse bilateral hamstring muscle (ST, semimembranosus, bicep femoris long head and short head) morphology and distal ST tendon insertion. The ACLR cohort was sub‐grouped into those with and without ST regeneration. For each participant with ST regeneration (n = 7), a personalized musculoskeletal model was created including postoperative remodeling of ST using OpenSim 4.1. Knee flexion and internal rotation moment arms and torque generating capacities of hamstrings were evaluated. Bilateral differences were calculated with an asymmetry index (%) ([unaffected limb–affected limb]/[unaffected limb + affected limb]*100%). Smaller moment arms or knee torques within injured compared to uninjured contralateral limbs were considered a deficit. Compared to uninjured contralateral limbs, ACLR limbs with tendon regeneration (n = 7) had minor reductions in knee flexion (5.80% [95% confidence interval (CI) = 3.97–7.62]) and internal rotation (4.92% [95% CI = 2.77–7.07]) moment arms. Decoupled from muscle morphology, altered ST moment arms in ACLR limbs with tendon regeneration resulted in negligible deficits in knee flexion (1.20% [95% CI = 0.34–2.06]) and internal rotation (0.24% [95% CI = 0.22–0.26]) torque generating capacity compared to uninjured contralateral limbs. Coupled with muscle morphology, ACLR limbs with tendon regeneration had substantial deficits in knee flexion (19.32% [95% CI = 18.35–20.28]) and internal rotation (15.49% [95% CI = 14.56–16.41]) torques compared to uninjured contralateral limbs. Personalized musculoskeletal models with measures of ST distal insertion and muscle morphology provided unique insights into post‐ACLR ST and hamstring function. Deficits in knee flexor and internal rotation moment arms and torque generating capacities were evident in those with ACLR even when tendon regeneration occurred. Future studies may wish to implement this framework in personalized musculoskeletal models following ACLR to better understand individual muscle function for injury prevention and treatment evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Joint Torque Analysismentioning

confidence: 99%

Moment arm and torque generating capacity of semitendinosus following tendon harvesting for anterior cruciate ligament reconstruction: A simulation study

du Moulin,

Bourne,

Diamond

et al. 2024

Journal Orthopaedic Research

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“…The tendons of the medial hamstring muscles are used as a source for auto graft, in the reconstruction of anterior cruciate ligament of the knee joint [ 11 ]. The ST muscle tendon graft is known to give powerful strength, because of its length and it is more suitable to bridge the larger gaps [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Morphometric study of the semitendinosus muscle and its neurovascular pedicles in South Indian cadavers

et al. 2018

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The purpose of this study was to determine the length of the semitendinosus muscle belly and its tendon in South Indian population and to study the topography and diameter of its neurovascular pedicles. The study included 46 formalin fixed human cadaveric lower limbs. The length of the semitendinosus muscle belly and its tendon were measured. The neurovascular pedicles of the semitendinosus muscle were identified and counted. The diameter of the neurovascular pedicle was measured just before its entrance into the semitendinosus muscle. The topographical distance of the neurovascular pedicles from the origin of the semitendinosus muscle were determined. The mean length of the semitendinosus muscle belly was 332.3±36.1 mm and its tendon measured 154.8±31.9 mm. The mean diameter of the vascular pedicle was measuring 11.4±9.1 mm, just before its entrance into the semitendinosus muscle. The neurovascular pedicles, of the semitendinosus muscle were ranging between 1 and 7. The distance of the entrance of neurovascular pedicle to the semitendinosus muscle from its origin was ranging between 46 and 272 mm. It was observed that the neurovascular pedicles were highest (31%) at the range of 151–200 mm away from the ischial tuberosity. The morphometric data obtained in the present study is enlightening to the orthopedic and plastic surgeons. The topographical knowledge of the neurovascular pedicles has its implications during the harvesting of the grafts and pedicle flaps. The diameter of vessels in the pedicles is enlightening because of new method of anterior cruciate ligament reconstruction.

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“…1 , 5 In 1992, Cross et al, 6 using magnetic resonance imaging (MRI) in 4 patients, demonstrated that these tendons present substantial regenerative potential. Since then, several authors have studied this potential from a macroscopic 7 – 10 as well as histological standpoint. 11 , 12 However, the literature on the regenerative capacity of the tendon, as well as its consistency and thickness, is unclear.…”

Section: Introductionmentioning

confidence: 99%

“…1 , 3 , 4 , 8 In this context, there is ample evidence in the literature indicating that tendons and ligaments are generally able to heal intrinsically. 9 , 10 The mechanisms involved in regeneration, according to Eriksson et al, can be both intrinsic and extrinsic in origin. 8 Extrinsic healing involves regeneration from the peritendinous tissue, with gradual invasion of capillaries and formation of granulation tissue.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Regeneration Capacity of Semitendinosus and Gracilis Tendons

et al. 2018

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Objectives:To evaluate the regenerative capacity of gracilis (G) and semitendinosus (ST) tendons, to examine the sensitivity and specificity of signs and symptoms in the assessment of hamstring tendons, and to assess the thickness and insertion site of regenerated tendons.Methods:Thirty sequential knees were subjected to anterior cruciate ligament reconstruction with semitendinosus and gracilis tendons. After surgery, the patients were followed up clinically with physical examination and magnetic resonance imaging (MRI).Results:Overall, 36.66% of the tendons were visible on MRI, whereas 83.33% were palpable. On MRI, the distal insertion site of the regenerated semitendinosus tendon was visible proximal to the landmark of the medial femoral condyle in 28%, at the same level in 16%, and distally in 56% of the cases. Gracilis tendon insertion was visible proximally in 36.66% of cases, at the same level in 10%, and distally in 53.33%. Eleven knees exhibited complete regeneration.Conclusion:Partial or total regeneration of the ST and G tendons was apparent on MRI. Palpation is effective for evaluating regeneration of the ST and G tendons; however, MRI is still the gold standard. ST and G tendons regenerated completely in only a small percentage of patients, limiting reuse as a graft in cases with new ligament injuries of the knee. Level of Evidence II, Prospective comparative study.

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Inducement of tissue regeneration of harvested hamstring tendons in a rabbit model

Cited by 3 publications

References 15 publications

Moment arm and torque generating capacity of semitendinosus following tendon harvesting for anterior cruciate ligament reconstruction: A simulation study

Moment arm and torque generating capacity of semitendinosus following tendon harvesting for anterior cruciate ligament reconstruction: A simulation study

Morphometric study of the semitendinosus muscle and its neurovascular pedicles in South Indian cadavers

Assessment of the Regeneration Capacity of Semitendinosus and Gracilis Tendons

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