Inducible antibacterial responses in macrophages

Sweet, Matthew J.; Ramnath, Divya; Singhal, Amit; Kapetanovic, Ronan

doi:10.1038/s41577-024-01080-y

Nat Rev Immunol

2024

DOI: 10.1038/s41577-024-01080-y

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Inducible antibacterial responses in macrophages

Matthew J. Sweet,

Divya Ramnath,

Amit Singhal

et al.

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2024

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Cited by 1 publication

References 227 publications

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Acetic acid induces osmotic imbalances in drug-resistant bacteria synergistically enhancing cobalt-doped carbon quantum dots bactericidal efficiency

Truskewycz,

Choi,

Pedersen

et al. 2024

Preprint

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When pathogenic bacteria colonise a wound, they can create an alkaline ecological niche which selects for their survival by creating an inflammatory environment which restricts healthy wound healing to proceed. To aid healing, wound acidification has been exploited to disrupt this process and stimulate fibroblast growth, increase wound oxygen concentrations, minimise proteolytic activity and re-stimulate the host immune system. Within this study, we have developed unique cobalt doped carbon quantum dot nanoparticles which work together with mild acetic acid creating a potent synergistic antimicrobial therapy. The acidic environment alters the osmotic balance of microorganisms forcing them to swell and speed up the internalisation of the ultra-small particles. The particles hyperpolarise the bacterial membranes and generate damaging peroxidase species resulting in cellular lysis. In mice, cobalt doped carbon quantum dots remove MRSA infection while allowing wounds to heal at equivalent rates to uninfected wounds. This work demonstrates how synergistic antimicrobial treatment strategies can be successfully used to combat antimicrobial resistant infections.

show abstract

Acetic acid induces osmotic imbalances in drug-resistant bacteria synergistically enhancing cobalt-doped carbon quantum dots bactericidal efficiency

Truskewycz,

Choi,

Pedersen

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Inducible antibacterial responses in macrophages

Cited by 1 publication

References 227 publications

Acetic acid induces osmotic imbalances in drug-resistant bacteria synergistically enhancing cobalt-doped carbon quantum dots bactericidal efficiency

Acetic acid induces osmotic imbalances in drug-resistant bacteria synergistically enhancing cobalt-doped carbon quantum dots bactericidal efficiency

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