Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells

Vocanson, Marc; Rozières, Aurore; Hennino, Anà; Poyet, Gaelle; Gaillard, Vincent; Renaudineau, Sarah; Achachi, Amine; Bénetière, Josette; Kaiserlian, Dominique; Dubois, Bertrand; Nicolas, Jean‐François

doi:10.1016/j.jaci.2010.05.022

Cited by 148 publications

(143 citation statements)

References 36 publications

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“…Furthermore, ICOS + Tregs expressed higher levels of the cell surface TGF-β/latency-associated peptide (TGF-β/LAP) than ICOS - T cells ( Figure 5C and Supplemental Figure 2). These results indicate that the ICOS + T cells may be highly suppressive, as described previously (36,37).…”

Section: Activated T Cells Within a Cd4 + Icos + Subset Greatly Incresupporting

confidence: 87%

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

Sim¹,

Martín‐Orozco

Jin³

et al. 2013

J. Clin. Invest.

201

172

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Section: Activated T Cells Within a Cd4 + Icos + Subset Greatly Incresupporting

confidence: 87%

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

Sim¹,

Martín‐Orozco

Jin³

et al. 2013

J. Clin. Invest.

201

172

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“…CD4 + Foxp3 + Tregs are critical regulators of CHS responses (5,8), and our recent data highlighted the unique suppressive potential of activated ICOS + CD4 + Foxp3 + Tregs in CHS to DNFB (7). Although DNTB painting did not affect the overall frequency of CD4 + Foxp3 + Tregs in skin-draining LNs (data not shown), the proportion of activated ICOS + cells among CD4 + Foxp3 + Tregs increased by 2-to 3-fold 5 days after tolerance induction ( Figure 7A), indicating that an innocuous and tolerogenic hapten can activate Tregs.…”

Section: (F and G)mentioning

confidence: 67%

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

Vocanson²,

et al. 2012

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Allergic contact dermatitis is the most frequent occupational disease in industrialized countries. It is caused by CD8 + T cell-mediated contact hypersensitivity (CHS) reactions triggered at the site of contact by a variety of chemicals, also known as weak haptens, present in fragrances, dyes, metals, preservatives, and drugs. Despite the myriad of potentially allergenic substances that can penetrate the skin, sensitization is relatively rare and immune tolerance to the substance is often induced by as yet poorly understood mechanisms. Here we show, using the innocuous chemical 2,4-dinitrothiocyanobenzene (DNTB), that cutaneous immune tolerance in mice critically depends on epidermal Langerhans cells (LCs), which capture DNTB and migrate to lymph nodes for direct presentation to CD8 + T cells. Depletion and adoptive transfer experiments revealed that LCs conferred protection from development of CHS by a mechanism involving both anergy and deletion of allergen-specific CD8 + T cells and activation of a population of T cells identified as ICOS + CD4 + Foxp3 + Tregs. Our findings highlight the critical role of LCs in tolerance induction in mice to the prototype innocuous hapten DNTB and suggest that strategies targeting LCs might be valuable for prevention of cutaneous allergy.

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“…S2a,b). IL-10-eGFP + CD8 + T cells in the skin had an effector memory phenotype [7] and characteristics of Treg cells [8] (Fig. S3a,b).…”

Section: Resultsmentioning

confidence: 99%

Contact allergens induce CD8⁺ T cell‐derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity

Dolch

Kunz

Dorn

et al. 2017

Experimental Dermatology

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Interleukin 10 (IL‐10) has been implied in the regulation of allergic contact dermatitis. Using transcriptional reporter mice we analyzed cellular sources of IL‐10 during contact hypersensitivity (CHS) and identified IL‐10 expressing CD8+ T cells in the skin that are antigen‐specific, display PD‐1, an effector memory phenotype, and IL‐10 expression comparable to that of CD4+ T cells. However, in mice with a selective IL‐10 deficiency in CD8+ T cells CHS responses were comparable to that of controls, even in the absence of CD4+ cells, suggesting that CD8+ T cell‐derived IL‐10 does not contribute significantly to the resolution of CHS responses.

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Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells

Cited by 148 publications

References 36 publications

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

Contact allergens induce CD8⁺ T cell‐derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity

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Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells

Cited by 148 publications

References 36 publications

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

Contact allergens induce CD8+ T cell‐derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity

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Contact allergens induce CD8⁺ T cell‐derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity