1988
DOI: 10.1093/clinids/10.4.830
|View full text |Cite
|
Sign up to set email alerts
|

Inducible  -Lactamases: Clinical and Epidemiologic Implications for Use of Newer Cephalosporins

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
81
0

Year Published

1991
1991
2017
2017

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 171 publications
(82 citation statements)
references
References 36 publications
1
81
0
Order By: Relevance
“…In this scenario, patients are treated with an appropriate ␤-lactam based on initial susceptibility data, only to fail therapy due to the emergence of AmpC-mediated resistance. This phenomenon has been observed in 14 to 56% of patients treated with antipseudomonal penicillins, penicillin-inhibitor combinations, aztreonam, and extended-spectrum cephalosporins (50,71,94,97,118,147,226,228,235), and emergence of resistance/ clinical failure is observed most frequently with infections outside the urinary tract and in patients with underlying cystic fibrosis and neutropenia. Although combining an aminoglyco- Inducing ␤-lactams, such as cefoxitin and imipenem, cross the outer membrane through porins, enter the periplasmic space, and interact with target PBPs.…”
Section: Clinical Significance Of Ampc Overproductionmentioning
confidence: 99%
See 2 more Smart Citations
“…In this scenario, patients are treated with an appropriate ␤-lactam based on initial susceptibility data, only to fail therapy due to the emergence of AmpC-mediated resistance. This phenomenon has been observed in 14 to 56% of patients treated with antipseudomonal penicillins, penicillin-inhibitor combinations, aztreonam, and extended-spectrum cephalosporins (50,71,94,97,118,147,226,228,235), and emergence of resistance/ clinical failure is observed most frequently with infections outside the urinary tract and in patients with underlying cystic fibrosis and neutropenia. Although combining an aminoglyco- Inducing ␤-lactams, such as cefoxitin and imipenem, cross the outer membrane through porins, enter the periplasmic space, and interact with target PBPs.…”
Section: Clinical Significance Of Ampc Overproductionmentioning
confidence: 99%
“…22,2009 ANTIBACTERIAL-RESISTANT PSEUDOMONAS AERUGINOSA 589 side with an antipseudomonal ␤-lactam is one strategy for preventing the emergence of AmpC-mediated resistance, this combination is not always effective in achieving that goal (97,118,147,226,228,235).…”
Section: Clinical Significance Of Ampc Overproductionmentioning
confidence: 99%
See 1 more Smart Citation
“…About 3 decades ago, resistance to these drugs appeared in gramnegative bacilli with chromosomally encoded β-lactamases, most often as the result of mutations that led to the constitutive production of these normally inducible enzymes [64]. Around the same period enteric gram-negative bacilli with transferable resistance to extended-spectrum cephalosporins were described [65].…”
Section: Important Pharmacological Aspectsmentioning
confidence: 99%
“…There is a number of veterinary products containing β-lactam antibiotics in their composition, which are used to control mastitis in cows (Bozhkova et al 1983, Guerrini et al 1985, Wilson et al 1986, Novelli et al 2000, Bradley et al 2002 One of the β-lactam antibiotic groups are cephalosporins, among others cefoperazone (CEF) (Guerrini et al 1985, Wilson et al 1986, Sanders et al 1988, Guterbock et al 1993, Costa et al 1998, Heringstad et al 2000, Novelli et al 2000, EC 2002, Błądek et al 2011. Cephalosporins are commonly used in veterinary medicine due to their broad spectrum of activity when confronted with natural penicillins, low treatment cost, and safety.…”
Section: Introductionmentioning
confidence: 99%