2016
DOI: 10.1016/j.lfs.2016.06.019
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Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat

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Cited by 57 publications
(30 citation statements)
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References 55 publications
(81 reference statements)
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“…Considering these facts, it seems that an excessive production of proinflammatory cytokines followed by injection of LPS plays an important role in spatial memory and synaptic plasticity deficits caused by LPS in the present study. Supporting this idea, we have previously shown that administration of LPS (1 mg/kg) increases serum TNF α levels [10, 16, 31]. …”
Section: Discussionmentioning
confidence: 92%
“…Considering these facts, it seems that an excessive production of proinflammatory cytokines followed by injection of LPS plays an important role in spatial memory and synaptic plasticity deficits caused by LPS in the present study. Supporting this idea, we have previously shown that administration of LPS (1 mg/kg) increases serum TNF α levels [10, 16, 31]. …”
Section: Discussionmentioning
confidence: 92%
“…It has been demonstrated that excessive production of free radicals and brain oxidative damage result in learning and memory deficits, and compounds with antioxidant properties can improve these processes 17 . Previously, we demonstrated the role of brain tissue oxidative damage in learning and memory deficits in rats 15 . Oxidative stress followed by PTU administration has also been suggested to have negative effects on learning and memory…”
Section: Discussionmentioning
confidence: 94%
“…On the probe day (sixth day), the platform was removed and the animals were allowed to swim for 60 seconds. The time spent and distance traveled in the target quadrant were recorded to compare between the groups 15 .…”
Section: Morris Water Maze Testmentioning
confidence: 99%
“…These include lipopolysaccharide (LPS)-, polyI C-, streptozotocin-, okadaic acid-and colchicine-induced neuroinflammation. LPS-induced neuroinflammation represents the current standard paradigm to study neuroinflammation both in vivo (Hauss-Wegrzyniak et al 1998, Sheng et al 2003, Anaeigoudari et al 2016) and in vitro (Candiracci et al 2012. There are several other non-genetically manipulated rat models of AD which are not limited to induced neuroinflammation.…”
Section: Non-genetically Manipulated Neuro-inflammation Models For Admentioning
confidence: 99%