Inducible NO synthase as a pharmacological target of anti-inflammatory therapy: hope is not lost?

Abstract

The review is devoted to the current assesment of the role of nitric oxide and inducible NO-synthase in physiological and pathological conditions. The inducible NO-synthase gene expression induction and post-transcriptional regulation of its activity are considered. Data on endogenous inducible NO-synthase inhibitors of are given. An analysis of the clinical trials aimed at studying the clinical efficacy of NO synthase inhibitors was carried out.