Inducible skin‐associated lymphoid tissue (iSALT) in a patient with Schnitzler syndrome who manifested wheals on recurrent localized erythema

Abstract

is 265 times the current exposure limit value of 23 mJ cm À2 at 222 nm. 7 Therefore, even at very high exposure doses, appropriately filtered far-UVC is unlikely to present a carcinogenic risk through direct DNA damage. These important but preliminary results are very encouraging. As recently advised and encouraged by the UK's Scientific Advisory Group for Emergencies we are continuing with multiple far-UVC research projects to investigate the efficacy and safety profile of this very promising technology. 8 However, to date, the evidence is overwhelmingly in favour of using filtered far-UVC as a safe, effective germicidal technology.

Skin‐associated lymphoid tissue could be a sign of systemic disease: reply from authors

“…Our case demonstrated a perivascular infiltration of neutrophils in the upper dermis, and lymphoid follicles with some plasma cells at the periphery only in the deeper dermis. 2 Castleman disease is classified into several subtypes depending on the clinical findings, and any subtype manifests lymphadenopathy, which was not detected by ultrasound and positron emission tomography/computed tomography in our patient. 3 Although Castleman disease usually exhibits IgG gammopathy, a subtype of POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome-associated multicentric Castleman disease is reported to display IgM monogammopathy, which was observed in our patient.…”

“…On the other hand, the administration of anakinra demonstrated prompt favourable responses to clinical manifestations. 2 Taken together, although the possibility of Castleman disease and cutaneous plasmacytosis cannot be completely excluded, our case is considered as Schnitzler syndrome.…”

“…Germinal centres with surrounding plasma cells and hypervascularity are not only seen in lymph nodes of patients with idiopathic multicentric Castleman disease but could also involve their bone marrow as well as skin. 2 The erythematous skin plaques are usually neither painful nor pruritic, and involve face and trunk. It could precede the development of other systemic features of idiopathic multicentric Castleman disease.…”

“…DEAR EDITOR, We thank Dr Wang for pointing out that Castleman disease and cutaneous plasmacytosis are potential differential diagnoses 1 in our case. 2 In general, Castleman disease and cutaneous plasmacytosis typically manifest as a 'Christmas tree-like' distribution of dark brownish nodules on the trunk. In addition, in Castleman disease and cutaneous plasmacytosis, the histopathology exhibits dense plasma cell accumulation in the dermis, which was not observed in our case.…”

Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue

“…Our group recently reported that lymphoid follicles in the skin exhibit immunohistochemical patterns analogous to those of lymph nodes, and therefore we defined these follicles as iSALT in humans (26)(27)(28)(29)(30). Similarly, many lymphoid follicles that fulfill the definition of TLS in histology-based studies have been identified in the salivary duct, in lachrymal drainage, in the Eustachian tube, and in the larynx (31).…”