Inducing femoral vein thrombosis under unrestricted flow: Comments on an alternative electrolytic mouse model

Hypoxia and HIF activation as a possible link between sepsis and thrombosis

“…These observations together suggest that increases in thrombus formation could be controlled by cell-specific HIFs, but despite evidence that systemic and endothelial hypoxia stimulate thrombosis [19, 20], the roles of endothelial cell-specific HIF1 and HIF2 in thrombus formation are unknown. Future studies should aim to assess the relative contributions of HIFs in different cell types to thrombus formation using genetically-altered mouse models and models of thrombosis [21–24].…”