1997
DOI: 10.1016/s0091-6749(97)70052-6
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Induction and differential regulation of bee venom phospholipase A2–specific human IgE and IgG4 antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells☆, ☆☆, ★, ★★

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Cited by 59 publications
(60 citation statements)
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“…The uncoupling of IgG4 and IgE has been described in several other studies on bee venom atopy (22)(23)(24). In atopic diseases where cross-linking of IgE molecules and Ag on mast cells seems to play a major role (25), disease exacerbation has been shown to be inversely associated with increasing IFN-␥ levels (24).…”
Section: Cd25mentioning
confidence: 79%
“…The uncoupling of IgG4 and IgE has been described in several other studies on bee venom atopy (22)(23)(24). In atopic diseases where cross-linking of IgE molecules and Ag on mast cells seems to play a major role (25), disease exacerbation has been shown to be inversely associated with increasing IFN-␥ levels (24).…”
Section: Cd25mentioning
confidence: 79%
“…Recently, it has been shown that IgG4-producing cells essentially develop from IL-10-secreting, CD25 + , CD71 + , CD73 + B regulatory cells (27). Thus, both IgG4 production and T cell tolerance against allergens during allergen-specific immunotherapy seem to develop in a network of IL-10-producing regulatory T and B cells (28)(29)(30). IgG4-producing cells can undergo secondary class switch to IgE (31), as was shown also for IgG1 in mice (32); thus, a fraction of the IgE repertoire may reflect a subset of the IgG4 repertoire in humans.…”
mentioning
confidence: 99%
“…However, there is a possibility that IL-10 produced by this type of Treg cells could have an important role in vivo. Allergic diseases are associated with high serum levels of allergen-specific IgE while normal response to allergens in healthy individuals is characterized by IgG Abs, especially of IgG4 class (46), which will compete with IgE Abs for binding to the allergen (47,48). Several studies show that there are increases in the levels of serum allergen-specific IgG4 following allergen-specific immunotherapy (14,49).…”
Section: Discussionmentioning
confidence: 99%