Induction and growth of mammary tumors after superior cervical ganglionectomy in sighted and blinded-anosmic rats

Chang, Nada; Tseng, Michael T.; Spaulding, Timothy S.

doi:10.1016/0024-3205(86)90136-0

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…It has been established that CR disruption under conditions of excessive constant lighting promotes cancerogenesis, and an application of exogenous melatonin leads to the inhibition of tumor growth in cases of both intact and disrupted circadian rhythms [ 26 , 27 , 28 , 29 , 30 ]. However, a number of authors observe such an effect of melatonin only under standard illumination but note the stimulation of tumor growth by this hormone under constant illumination [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristic of Ultrastructure of Mice B16 Melanoma Cells under the Influence of Different Lighting Regimes

et al. 2022

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Circadian rhythms of physiological processes, constantly being in a state of dynamic equilibrium and plastically associated with changes in environmental conditions, are the basis of homeostasis of an organism of human and other mammals. Violation of circadian rhythms due to significant disturbances in parameters of main environmental effectors (desynchronosis) leads to the development of pathological conditions and a more severe course of preexisting pathologies. We conducted the study of the ultrastructure of cells of mice transplantable malignant melanoma B16 under the condition of normal (fixed) lighting regime and under the influence of constant lighting. Results of the study show that melanoma B16 under fixed light regime represents a characteristic picture of this tumor—predominantly intact tissue with safe junctions of large, functionally active cells with highly irregular nuclei, developed organelles and a relatively low content of melanin. The picture of the B16 melanoma tissue structure and the ultrastructure of its cells under the action of constant lighting stand in marked contrast to the group with fixed light: under these conditions the tumor exhibits accelerated growth, a significant number of cells in the state of apoptosis and necrosis, ultrastructural signs of degradation of the structure and functions, and signs of embryonization of cells with the background of adaptation to oxygen deficiency.

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