Induction by young of prolonged dioestrus in virgin rats behaving maternally

Jakubowski, Moshe; Terkel, Joseph

doi:10.1530/jrf.0.0580055

Cited by 15 publications

(3 citation statements)

References 20 publications

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“…Extended periods of maternal experience have been reported to affect vaginal cyclicity (Erskine, Barfield, & Goldman, 1980) as well as prolactin (Koranyi, Phelps, & Sawyer, 1977;Stern & Siegel, 1978; Samuels & Bridges, Note 1) and corticosterone (Koranyi et al, 1977) secretion in virgin and primiparous rats. Furthermore, prolonged periods of diestrus similar to those shown by pseudopregnant and lactating rats were recently found in maternal virgin female rats (Jakubowski & Terkel, 1980). These data suggest to us that the reinduced nulliparous females in our study may have been endocrinologically and behaviorally comparable to lactating rats.…”

Section: Discussionsupporting

confidence: 86%

Retention of maternal behavior in nulliparous and primiparous rats: Effects of duration of previous maternal experience.

Cohen¹,

Bridges²

1981

Journal of Comparative and Physiological Psychology

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Section: Discussionsupporting

confidence: 86%

Retention of maternal behavior in nulliparous and primiparous rats: Effects of duration of previous maternal experience.

Cohen¹,

Bridges²

1981

Journal of Comparative and Physiological Psychology

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“…Ovarian cycling is suspended in postpartum females (e.g., van der Shoot, Lankhorst, de Roo, and de Greef, 1978), but may or may not be suspended in virgin females continuously exposed to pups (Jakubowski and Terkel, 1980;Marinari and Moltz, 1978;Fleming and Rosenblatt, 1974). To determine any effects of ovarian cyclicity on sensitization or subsequent maternal behavior in the virgin females, we observed the behavior of both ovariectomized and gonadally intact maternal virgins.…”

Section: Subjectsmentioning

confidence: 99%

Comparison of the “Nursing” and Other Parental Behaviors of Nulliparous and Lactating Female Rats

Lonstein

Wagner

Vries

1999

Hormones and Behavior

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“…parturition (23)(24)(25)(26). Similarly, prolonged diestrus (27) and pseudopregnancy induced by suckling (24,27,28) are characterized by high progestcronc concentrations, ending with an estrus and increased estrogen Icvels. Preliminary observations from our own laboratory indicate that a minimum period of estrogen exposure is important, since 4 days of progesterone treatment followed by only 8 h of estrogen.…”

Section: Discussionmentioning

confidence: 99%

Influence of Ovarian Steroids on the Ultrastructural Plasticity of the Adult Rat Supraoptic Nucleus Induced by Central Administration of Oxytocin

Montagnese

Poulain

Theodosis

1990

J Neuroendocrinology

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In earlier studies, we showed that continuous intracerebroventricular infusion of oxytocin, for several days, into the third ventricle of normally hydrated, non-lactating adult female rats significantly reduced glial coverage of magnocellular oxytocinergic neurons in the hypothalamus. It also induced synaptic remodelling whereby many oxytocinergic neurons became synaptically contacted by the same presynaptic terminals (shared synapses). Such changes were closely similar to those observed in the oxytocinergic system when it is physiologically activated, as during parturition and lactation.We now report that central oxytocin does not act alone to modify the ultrastructure of the magnocellular nuclei, but requires the concomitant action of sex steroids. lntracerebroventricular infusion of oxytocin was effective in inducing neuronal-glial and synaptic changes only in supraoptic nuclei of female rats undergoing a prolonged diestrus, or in castrated female rats treated during the infusion period with daily intramuscular injections of progesterone for 4 days followed by 17p-estradiol for 2 days. Infusion of oxytocin in rats with regular estrous cycles, or in castrated rats treated with progesterone or estrogen alone had no effect on the ultrastructure of the nucleus. Our observations also indicate that the action of oxytocin on the anatomy of its own neurons is very specific: only 4-threonine-oxytocin, a closely related oxytocin analogue, had an effect similar to that of oxytocin; vasopressin, 4-threonine-7-glycine oxytocin and cholecystokinin left the magnocellular nuclei structurally unaltered.The neurohypophysial hormone, oxytocin, is released no1 only into the peripheral circulation but also centrally. Changing levels of oxytocin can be detected in the cerebrospinal fluid (CSF) (1-3) and within the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei (4-6), where oxytocin-secreting neurons are concentrated.A major feature to emerge from recent studies is that central oxytocin can modify both the activity and anatomy of oxytocinsecreting neurons, within the hypothalamic nuclei. Functionally, after injection into the third ventricle of lactating animals, oxytocin facilitated the electrical activity of oxytocin neurons and increased the frequency of reflex milk ejection (7, 8). Anatomically, continuous intracerebroventricular (icv) infusion of oxytocin for several days, in normally hydrated, non-lactating adult female rats, significantly increased the incidence of directly juxtaposed and synaptically coupled oxytocin neurons (9). The morphological changes were closely similar to those observed when the system is under physiological activation, as during parturition and lactation (10. 11).The mechanisms by which central oxytocin affects the ultrastructure of the oxytocinergic centres remain undetermined, but several observations led us to believe that sex steroids may be involved in its action. For example, the oxytocinergic system always appears structurally modified during parturition and postpartum...

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Induction by young of prolonged dioestrus in virgin rats behaving maternally

Abstract: Summary. The present investigation examined, by study of daily vaginal smears, whether the interaction of virgin female rats with young affected the oestrous cycle. Virgins behaving non-maternally or maternally were continuously exposed to young for extended periods. (1)

Cited by 15 publications

References 20 publications

Retention of maternal behavior in nulliparous and primiparous rats: Effects of duration of previous maternal experience.

Retention of maternal behavior in nulliparous and primiparous rats: Effects of duration of previous maternal experience.

Comparison of the “Nursing” and Other Parental Behaviors of Nulliparous and Lactating Female Rats

Influence of Ovarian Steroids on the Ultrastructural Plasticity of the Adult Rat Supraoptic Nucleus Induced by Central Administration of Oxytocin

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