Induction Chemotherapy for Advanced Squamous Cell Carcinoma of the Paranasal Sinuses

Abstract

Tumor response to induction chemotherapy in patients with advanced squamous cell carcinoma of the paranasal sinuses may be predictive of treatment outcome and prognosis. Favorable response to induction chemotherapy is associated with better survival and a reasonable chance of organ preservation.

The role of systemic therapy in the management of sinonasal cancer: A critical review

“…Hanna et al reported on a retrospective series of 46 patients with previously untreated biopsy-proven SCC of the paranasal sinuses treated with induction chemotherapy at the MD Anderson Cancer Center (MDACC) in the US [29]. Eighty percent of patients had stage IV disease, 67% had orbital invasion and 26% had nodal metastases.…”

“…The choice of the type of chemotherapy according to histologically defined tumor type has not been specifically addressed in the reported trials. However, most of the previously reported studies employed platinum-based chemotherapy in combination with either 5-fluorouracil, taxane, ifosfamide, or vincristine [25][26][27][28][29].…”

Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience

“…outcomes for patients with SCC of the paranasal sinuses [11], and NAC followed by CRT is also considered to be an option for locally advanced NC&ES.…”

Surgery in the Multimodality Treatment of Sinonasal Malignancies

“…Generally, these reports contain small numbers of patients with relatively short follow-ups. 13 For esthesioneuroblastoma, local recurrences can develop 10 years or more after the completion of treatment, so prolonged follow-up is needed. With surgical techniques changing rapidly, craniofacial resection remains an important standard by which other treatments for esthesioneuroblastoma should be judged.…”

“…Long-term outcomes and toxicity results are still pending. 13 Although chemosensitivity may identify patients with a better prognosis, it is unlikely that patients who progressed during chemotherapy benefited from the delay in definitive local treatment. The role of induction chemotherapy in the setting of paranasal sinus cancer remains under investigation.…”