Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma

Lilly, Gabriela L.; Geltzeiler, Mathew

doi:10.1055/s-0041-1736160

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current treatment paradigms typically include surgical resection aimed at achieving negative margins, followed by adjuvant radiotherapy and chemotherapy, depending on a multitude of disease and pathologic factors . Others have advocated for an induction chemotherapy approach in cases of locoregionally advanced disease …”

Section: Introductionmentioning

confidence: 99%

“…2,5 Others have advocated for an induction chemotherapy approach in cases of locoregionally advanced disease. 6,7 There are multiple oncogenic drivers for SNSCC, such as high-risk human papillomavirus (HPV), gene fusions including the DEK::AFF2 fusion, epidermal growth factor receptor alterations, or carcinogens. 8 When considering HPV as an etiologic agent, HPV-associated SNSCC has a propensity to arise in the nasal cavity and ethmoid sinus, whereas HPVindependent SNSCC has a propensity for the maxillary sinus and other sinonasal subsites.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Epidemiologic Trends in Human Papillomavirus–Associated Sinonasal Squamous Cell Carcinoma

Amanian,

Ishii,

Fakhry

et al. 2024

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

ImportanceSinonasal squamous cell carcinoma (SNSCC) is the most commonly encountered cancer within the sinonasal cavity. Ongoing research has sought to ascertain the potential role of human papillomavirus (HPV) in the pathogenesis of SNSCC.ObjectiveTo assess trends in HPV-associated and HPV-independent SNSCC over time, including assessment of clinical demographics, treatment patterns, and survival.Design, Setting, and ParticipantsThis cohort study used patient data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program database between 1975 and 2018. Anatomic sites with a greater predilection for HPV positivity (ie, nasal cavity, ethmoid sinus) were used as a surrogate for HPV-associated SNSCC; meanwhile, patients with SNSCC in the other subsites were classified into the HPV-independent group. Data were analyzed from August 2022 to May 2023.Main Outcomes and MeasuresClinical demographics and mortality trends over time were described for the HPV-associated and HPV-independent groups and further stratified according to stage on presentation.ResultsThe study population consisted of 3752 patients with SNSCC (mean [SD] age at diagnosis, 65.7 [13.3] years; 2417 [64.4%] male), with 1983 (52.9%) having HPV-associated SNSCC and 1769 (47.1%) with HPV-independent SNSCC. Patients with HPV-associated subsites compared with patients with HPV-independent SNSCC were more likely to present with localized disease (838 [42.3%] vs 162 [9.2%]), whereas more patients in the HPV-independent group than HPV-associated group presented with regional disease (1018 [57.5%] vs 480 [24.2%]). Incidence-based mortality was stable over time within the HPV-associated group (0.32%) and, conversely, showed a significant decrease within the HPV-independent group (−2.29%). Patients with HPV-associated SNSCC had a higher 5-year overall survival when compared with the HPV-independent group (62% vs 35% [difference, 27 percentage points; 95% CI, 23-31 percentage points]). The better 5-year overall survival in the HPV-associated group vs HPV-independent group was present across all disease stages (localized: hazard ratio [HR], 2.67; 95% CI, 1.96-3.65; regional: HR, 1.53; 95% CI, 1.29-1.82; and distant: HR, 1.97; 95% CI, 1.52-2.55).Conclusions and RelevanceThis cohort study showed that the proportion of HPV-associated SNSCC rose over time associated with both a rise in the proportion of nasal cavity SNSCC and a decrease in HPV-independent maxillary sinus SNSCC. These data suggest that HPV-associated SNSCC has a distinct demographic and prognostic profile, given the improved survival seen in patients with HPV-associated SNSCC.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Epidemiologic Trends in Human Papillomavirus–Associated Sinonasal Squamous Cell Carcinoma

Amanian,

Ishii,

Fakhry

et al. 2024

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Panelsequenzierung in der Kopf-Hals-Onkologie am Beispiel von sinunasalen und Speicheldrüsenmalignomen

Agaimy

Müller

2022

Onkologie

View full text Add to dashboard Cite

Surgical margins in head and neck squamous cell carcinoma: a narrative review

Chen,

Zhong,

Cao

et al. 2024

International Journal of Surgery

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC), a prevalent and frequently recurring malignancy, often necessitates surgical intervention. The surgical margin (SM) plays a pivotal role in determining the postoperative treatment strategy and prognostic evaluation of HNSCC. Nonetheless, the process of clinical appraisal and assessment of the SMs remains a complex and indeterminate endeavor, thereby leading to potential difficulties for surgeons in defining the extent of resection. In this regard, we undertake a comprehensive review of the suggested surgical distance in varying circumstances, diverse methods of margin evaluation, and the delicate balance that must be maintained between tissue resection and preservation in head and neck surgical procedures. This review is intended to provide surgeons with pragmatic guidance in selecting the most suitable resection techniques, and in improving patients’ quality of life by achieving optimal functional and aesthetic restoration.

show abstract

Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma

Cited by 4 publications

References 8 publications

Epidemiologic Trends in Human Papillomavirus–Associated Sinonasal Squamous Cell Carcinoma

Epidemiologic Trends in Human Papillomavirus–Associated Sinonasal Squamous Cell Carcinoma

Panelsequenzierung in der Kopf-Hals-Onkologie am Beispiel von sinunasalen und Speicheldrüsenmalignomen

Surgical margins in head and neck squamous cell carcinoma: a narrative review

Contact Info

Product

Resources

About