Induction Chemotherapy or Chemoradiotherapy Followed by Radical Esophagectomy for T4 Esophageal Cancer: Results of a Prospective Cohort Study

Shimoji, Hideaki; Karimata, Hiroyuki; Nagahama, Masayoshi; Nishimaki, Tadashi

doi:10.1007/s00268-013-2074-x

Cited by 39 publications

(33 citation statements)

References 26 publications

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“…Five (28 %) of the 18 patients showed pCR. For unresectable esophageal cancer, resectable rates, R0 rates, and pCR rates by preoperative CRT have been reported as 62-78, 39-71 and 13-25 %, respectively [19][20][21]. In our series, the resectable rate and pCR rate were similar to other reports, but the R0 rate was as high as 100 %.…”

Section: Discussionsupporting

confidence: 82%

Clinical results of definitive-dose (50 Gy/25 fractions) preoperative chemoradiotherapy for unresectable esophageal cancer

et al. 2014

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Section: Discussionsupporting

confidence: 82%

Clinical results of definitive-dose (50 Gy/25 fractions) preoperative chemoradiotherapy for unresectable esophageal cancer

et al. 2014

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“…Previously reported data have shown a close relationship between neoadjuvant chemoradiotherapy with increased mortality and esophageal surgery. 24 …”

Section: Discussionmentioning

confidence: 99%

The PER (Preoperative Esophagectomy Risk) Score

Reeh

Metze

Uzunoğlu³

et al. 2016

Medicine

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Esophageal resection in patients with esophageal cancer (EC) is still associated with high mortality and morbidity rates. We aimed to develop a simple preoperative risk score for the prediction of short-term and long-term outcomes for patients with EC treated by esophageal resection.In total, 498 patients suffering from esophageal carcinoma, who underwent esophageal resection, were included in this retrospective cohort study. Three preoperative esophagectomy risk (PER) groups were defined based on preoperative functional evaluation of different organ systems by validated tools (revised cardiac risk index, model for end-stage liver disease score, and pulmonary function test). Clinicopathological parameters, morbidity, and mortality as well as disease-free survival (DFS) and overall survival (OS) were correlated to the PER score.The PER score significantly predicted the short-term outcome of patients with EC who underwent esophageal resection. PER 2 and PER 3 patients had at least double the risk of morbidity and mortality compared to PER 1 patients. Furthermore, a higher PER score was associated with shorter DFS (P < 0.001) and OS (P < 0.001). The PER score was identified as an independent predictor of tumor recurrence (hazard ratio [HR] 2.1; P < 0.001) and OS (HR 2.2; P < 0.001).The PER score allows preoperative objective allocation of patients with EC into different risk categories for morbidity, mortality, and long-term outcomes. Thus, multicenter studies are needed for independent validation of the PER score.

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“…This corresponds with results published in previously published articles. 5,7,8,28,29 This study has some limitations. The relatively small cohort of patients treated with iCT limits the accuracy of the multivariable analysis.…”

Section: Characteristicmentioning

confidence: 94%

Induction chemotherapy followed by surgery for advanced oesophageal cancer

Toxopeus

Talman

Gaast

et al. 2015

European Journal of Surgical Oncology (EJSO)

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Induction Chemotherapy or Chemoradiotherapy Followed by Radical Esophagectomy for T4 Esophageal Cancer: Results of a Prospective Cohort Study

Abstract: Satisfactory survival rates can be achieved if R0 resection is performed after induction treatment in patients with T4 esophageal cancer, although secondary radical esophagectomy is associated with a higher risk of in-hospital mortality.

Cited by 39 publications

References 26 publications

Clinical results of definitive-dose (50 Gy/25 fractions) preoperative chemoradiotherapy for unresectable esophageal cancer

Clinical results of definitive-dose (50 Gy/25 fractions) preoperative chemoradiotherapy for unresectable esophageal cancer

The PER (Preoperative Esophagectomy Risk) Score

Induction chemotherapy followed by surgery for advanced oesophageal cancer

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