Induction Chemotherapy with or without Radiotherapy Followed by Surgery in Non-Small Cell Lung Cancer

Albain, Kathy S.

doi:10.1007/978-3-642-59824-1_5

Cited by 4 publications

(7 citation statements)

References 44 publications

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“…der Induktions-Chemo-Radiotherapie vor chirurgischer Resektion nicht-kleinzelliger Lungencarcinome des Stadiums III wird immer noch kontrovers betrachtet [3,20,21,24]. der Induktions-Chemo-Radiotherapie vor chirurgischer Resektion nicht-kleinzelliger Lungencarcinome des Stadiums III wird immer noch kontrovers betrachtet [3,20,21,24].…”

Section: Induktions-chemo-radiotherapie ± Phase-ii-studienunclassified

“…Hinzu kommt, dass auch die Position der Chirurgie in diesem Stadium III besonders bei groûer Primärtumormasse (Bulky disease) unklar ist. Dies gilt in gleicher Weise für die Induktions-Chemotherapie oder Induktions-Chemo-Radiotherapie [3]. Bemerkenswert ist in diesem Zusammenhang, dass in der Studie SWOG 8805 [2] 12 von 26 Operationspräparaten von Patienten mit dem Resultat ¹stable diseaseª nach Induktions-Chemotherapie eine komplette pathologische Response aufwiesen oder nur vereinzelte mikroskopisch nachweisbare Tumorreste enthielten.…”

Section: Induktions-chemo-radiotherapie ± Phase-ii-studienunclassified

“…Andere Autoren bestätigten diese Ergebnisse [3,53,67]. So war in der SWOG-Studie 8805 die mediane Überlebensdauer der Patienten nach Induktions-Chemo-Radiotherapie mit 9 Monaten sehr kurz, wenn noch Tumorgewebe in den mediastinalen Lymph-knoten nachweisbar war.…”

Section: Induktions-chemo-radiotherapie ± Phase-ii-studienunclassified

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Differentialindikation zur Induktionstherapie bei nicht-kleinzelligen Lungentumoren

Drings¹,

Manegold²

2000

Chirurg

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Induction chemotherapy and induction chemo-radiotherapy have shown their efficiency and feasibility in many phase-II studies and have profen superior to operation alone in stage IIIa of NSCLC in several phase-III studies. Therefore it is justified to recommend this multimodal therapy in stage IIIa N2 disease within clinical studies. However, it is currently not justified to present this multimodal treatment modality as a generally agreed standard.

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Section: Induktions-chemo-radiotherapie ± Phase-ii-studienunclassified

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Differentialindikation zur Induktionstherapie bei nicht-kleinzelligen Lungentumoren

Drings¹,

Manegold²

2000

Chirurg

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“…These trials varied widely in the definition of "bulky" disease and used different protocol mandates for resection after induction therapy (resection of stable disease also, or only resection of the responding tumors). These and other factors [4] potentially influence outcome apart from therapy rendered and make comparison across trials difficult.…”

Section: Introductionmentioning

confidence: 98%

“…Over the last 15 years, the role of induction chemotherapy with or without radiotherapy (RT) before surgical resection in non-small-cell lung cancer (NSCLC) has been debated [1][2][3][4][5]. This role has been addressed within numerous phase II and a few phase III studies.…”

Section: Introductionmentioning

confidence: 99%

Induction chemotherapy or chemoradiotherapy before surgery for non-small-cell lung cancer

Albain

2000

Curr Oncol Rep

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Two controversies regarding the role of induction therapy before surgery in non-small-cell lung cancer are considered through a review of the literature and ongoing trials worldwide. The first debate asks whether surgery is indicated after induction chemotherapy or chemoradiotherapy for patients with advanced stage III disease. The second debate addresses disease presentations with early stage disease or radiographically negative but microscopically positive N2 involvement. The question raised for this group of patients is whether induction chemotherapy with or without radiotherapy should be routinely prescribed before the standard therapy of definitive surgery. For both controversies, data are provocative and in some subsets argue in favor of the more aggressive approach. However, changes in standard-of-care recommendations are premature. Thus, ongoing worldwide trials maintain control arms of chemoradiotherapy alone and of surgery alone in the advanced and early disease subsets, respectively.

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Preoperative chemotherapy in stage III non-small cell lung cancer: long-term outcome

Gandara¹,

Leigh²,

Vallières

et al. 1999

Lung Cancer

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Induction Chemotherapy with or without Radiotherapy Followed by Surgery in Non-Small Cell Lung Cancer

Cited by 4 publications

References 44 publications

Differentialindikation zur Induktionstherapie bei nicht-kleinzelligen Lungentumoren

Differentialindikation zur Induktionstherapie bei nicht-kleinzelligen Lungentumoren

Induction chemotherapy or chemoradiotherapy before surgery for non-small-cell lung cancer

Preoperative chemotherapy in stage III non-small cell lung cancer: long-term outcome

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