Induction Course for Hospital Medical Staff

Abstract

249epithelial elements as the result of drug metabolite toxicity rather than as malignant change.Cyclophosphamide, in common with other cytotoxic agents, can under experimental conditions produce malignant change in laboratory animals. However, it is not one of those that has been known to produce malignancy in humans treated with cytotoxic drugs for non-malignant disease or for suppression of homograft rejection. However, one case of a second malignancy (myeloblastic leukaemia) occurring in a patient on long-term cyclophosphamide for a first malignancy (of the ovary) has been reported,3 and though this hazard may be less with cyclophosphamide than with certain other cytotoxic drugs, it should be borne in mind. -I am, etc.,