2022
DOI: 10.1101/2022.05.27.22275653
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Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children

Abstract: BACKGROUND: RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play the major role in vaccine-induced immunity, but knowledge on the induction, decay, and determinants of antibody function is limited, especially among children. Antibodies that promote opsonic phagocytosis and other cellular functions appear to be important contributors to RTS,S immunity. METHODS: We studied a phase IIb trial of RTS,S/AS… Show more

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