Induction dose and recovery quality of propofol and alfaxalone with or without midazolam coinduction followed by total intravenous anesthesia in dogs

Liao, PenTing; Sinclair, Melissa; Valverde, Alexander; Mosley, Craig; Chalmers, Heather; Mackenzie, Shawn; Hanna, Brad

doi:10.1016/j.vaa.2017.02.011

Cited by 29 publications

(23 citation statements)

References 31 publications

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“…Induction was made either with propofol and saline, propofol with midazolam, alfaxalone with saline or alfaxalone with midazolam. The results of the study showed a decrease in the induction doses of propofol and alfaxalone, as well as an improvement in the quality of induction and a decrease in the rate of propofol used for TIVA (Liao P. et al, 2017).…”

Section: Pre-anesthetic Management and Anesthesia Protocols In Animalmentioning

confidence: 87%

Anesthesia protocols and techniques for imaging diagnosis procedures in small animals

Degan¹,

Şonea²

2019

Rom Biotechnol Lett.

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Nowadays, imaging diagnosis play an important role in veterinary medicine, magnetic resonance imaging (MRI) being considered the top tool in diagnosing pathologies of different tissues and organs. Same as in pediatric medicine, this procedure has an impediment, represented by general anesthesia, whose effects upon the organism can increase risks. The importance of anesthesia during imaging diagnosis stands in the fact that the patients have to be motionless in order to achieve good quality images. General anesthesia for small animals during these procedures can be done with either the use of a total intravenous anesthesia or by using inhalation anesthesia. Both techniques described in studies have provided good results and are intended in helping practitioners all over the world. The purpose of this article is to highlight the most common anesthetic protocols and risks associated with them, as well as the aspects most seen by an anesthetist and imagist during an MRI scan.

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Section: Pre-anesthetic Management and Anesthesia Protocols In Animalmentioning

confidence: 87%

Anesthesia protocols and techniques for imaging diagnosis procedures in small animals

Degan¹,

Şonea²

2019

Rom Biotechnol Lett.

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“…Anesthetic induction with etomidate may produce some adverse effects like excitement, myoclonus or vomiting (Muir and Mason, 1989), thus midazolam was combined to counteract these effects. Most likely, midazolam may reduce the dose of etomidate as when it is combined with other common induction agents such as propofol or alfaxalone (Liao et al ., 2017). Although midazolam may reduce systolic blood pressure during co-induction with propofol in healthy dogs, values remained within an acceptable range (Hopkins et al ., 2014).…”

Section: Discussionmentioning

confidence: 99%

Anesthetic management of a dog with severe subaortic stenosis and mitral valve disease complicated with atrial fibrillation undergoing ovariohysterectomy

2019

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The anesthetic management in patients with subaortic stenosis and mitral valve disease should involve intensive monitoring and the anesthesiologist’s main concern is to ensure oxygen delivery and tissue perfusion. Since anesthetic procedures in such patients are rare, there is no previous report about the anesthetic management. A 5.5-year old, 32-kg Boxer, suffering a severe heart disease due to a final stage subaortic stenosis and mitral insufficiency, was anesthetized for an ovariohysterectomy to remove an ovarian tumor that was producing high-volume ascites. Methadone (0.3 mg kg −1 ) was administered intramuscularly (IM) for pre-anesthetic medication, etomidate (1.3 mg kg −1 ) and midazolam (0.2 mg kg −1 ) were used for the induction of anesthesia and after endotracheal intubation, anesthesia was maintained with sevoflurane vaporized in oxygen and air. Fentanyl (5–10 μg kg −1 h −1 ) and paracetamol (15 mg kg −1 ) were administered to improve analgesia. Previous persistent atrial fibrillation was refractory to medication (digoxin, diltiazem, and pimobendan) and continued during the anesthetic procedure. Dobutamine (1.5–5 μg kg −1 minute −1 ) helped to maintain mean arterial blood pressure above 60 mmHg. Epidural morphine (0.1 mg kg −1 ) and incisional bupivacaine (2 mg kg −1 ) were administered at the end of surgery to provide postoperative analgesia. Anesthesia was otherwise uneventful, and recovery was considered excellent.

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“…After administration of an opioid to healthy dogs, the median (range) dose of alfaxalone needed to induce anaesthesia was 1.67 (0.98 to 2.5 mg/kg) (Maddern et al 2010, Pinelas et al 2014, Raisis et al 2015, Liao et al 2017, Bennett et al 2019. In presence of a systemic disease, alfaxalone 1.9 (± 0.29) mg/kg was necessary to achieve endotracheal intubation (Psatha et al 2011).…”

Section: Factors Affecting the Induction Dosementioning

confidence: 99%

Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs

Bellido¹,

Vettorato²

2021

J of Small Animal Practice

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This clinical review summarises the pharmacological and anaesthetic properties of alfaxalone in the dog. Available pharmacokinetic‐pharmacodynamic data and factors affecting the induction dose have been reported. Furthermore, quality of induction and recovery after alfaxalone administration, the use of alfaxalone for total intravenous anaesthesia, and its effects on the cardio‐respiratory system, on laryngeal motion, on intraocular pressure and tear production have been evaluated. Finally, the use of alfaxalone in dogs undergoing caesarean section and the effect of intramuscular alfaxalone administration have been considered.

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Induction dose and recovery quality of propofol and alfaxalone with or without midazolam coinduction followed by total intravenous anesthesia in dogs

Cited by 29 publications

References 31 publications

Anesthesia protocols and techniques for imaging diagnosis procedures in small animals

Anesthesia protocols and techniques for imaging diagnosis procedures in small animals

Anesthetic management of a dog with severe subaortic stenosis and mitral valve disease complicated with atrial fibrillation undergoing ovariohysterectomy

Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs

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