Induction heating and in vitro cytotoxicity studies of MnZnFe2O4 nanoparticles for self-controlled magnetic particle hyperthermia

Jadhav, Swati V.; Kim, B.M.; Lee, H.Y.; Im, Inchul; Rokade, Ashish A.; Park, S.S.; Patil, Maheshkumar Prakash; Kim, G.D.; Yang, Yu; Lee, S.H.

doi:10.1016/j.jallcom.2018.02.174

Cited by 50 publications

(25 citation statements)

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“…The applications of nanomaterials in the biomedical field allows solving many issues such as targeted drug delivery [ 1 , 2 ], contrast-enhancing dye in magnetic resonance imaging (MRI) [ 3 , 4 , 5 , 6 , 7 , 8 ], mediators for hyperthermia applications [ 9 , 10 , 11 , 12 , 13 , 14 ], cell labeling and tracking [ 15 ], angiography with MRI [ 16 , 17 , 18 ], cellular transfection using magnetic fields [ 19 ], cerebral blood volume (CBV) experiments of functional MRI (fMRI) [ 20 ], drug distribution in the brain [ 21 ], and antimicrobial activity agent [ 22 ]. Surface functionalized/modified spinel ferrite nanoparticles such as MnFe 2 O 4 , MgFe 2 O 4 , CoFe 2 O 4 , ZnFe 2 O 4 , Fe 3 O 4 are excellent mediators for cancer thermotherapy and MRI contrast agents [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…The applications of nanomaterials in the biomedical field allows solving many issues such as targeted drug delivery [1,2], contrast-enhancing dye in magnetic resonance imaging (MRI) [3][4][5][6][7][8], mediators for hyperthermia applications [9][10][11][12][13][14], cell labeling and tracking [15], angiography with MRI [16][17][18], cellular transfection using magnetic fields [19], cerebral blood volume (CBV) experiments of functional MRI (fMRI) [20], drug distribution in the brain [21], and antimicrobial activity agent [22]. Surface [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

et al. 2020

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We synthesized manganese ferrite (MnFe2O4) nanoparticles of different sizes by varying pH during chemical co-precipitation procedure and modified their surfaces with polysaccharide chitosan (CS) to investigate characteristics of hyperthermia and magnetic resonance imaging (MRI). Structural features were analyzed by X-ray diffraction (XRD), high-resolution transmission electron microscopy (TEM), selected area diffraction (SAED) patterns, and Mössbauer spectroscopy to confirm the formation of superparamagnetic MnFe2O4 nanoparticles with a size range of 5–15 nm for pH of 9–12. The hydrodynamic sizes of nanoparticles were less than 250 nm with a polydispersity index of 0.3, whereas the zeta potentials were higher than 30 mV to ensure electrostatic repulsion for stable colloidal suspension. MRI properties at 7T demonstrated that transverse relaxation (T2) doubled as the size of CS-coated MnFe2O4 nanoparticles tripled in vitro. However, longitudinal relaxation (T1) was strongest for the smallest CS-coated MnFe2O4 nanoparticles, as revealed by in vivo positive contrast MRI angiography. Cytotoxicity assay on HeLa cells showed CS-coated MnFe2O4 nanoparticles is viable regardless of ambient pH, whereas hyperthermia studies revealed that both the maximum temperature and specific loss power obtained by alternating magnetic field exposure depended on nanoparticle size and concentration. Overall, these results reveal the exciting potential of CS-coated MnFe2O4 nanoparticles in MRI and hyperthermia studies for biomedical research.

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Section: Introductionmentioning

confidence: 99%

“…The applications of nanomaterials in the biomedical field allows solving many issues such as targeted drug delivery [1,2], contrast-enhancing dye in magnetic resonance imaging (MRI) [3][4][5][6][7][8], mediators for hyperthermia applications [9][10][11][12][13][14], cell labeling and tracking [15], angiography with MRI [16][17][18], cellular transfection using magnetic fields [19], cerebral blood volume (CBV) experiments of functional MRI (fMRI) [20], drug distribution in the brain [21], and antimicrobial activity agent [22]. Surface [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

et al. 2020

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“…Here, the product A · B is the initial rate of the temperature rise. It is equivalent to the ratio d T /d t in the following equation [49–50]:…”

Section: Resultsmentioning

confidence: 99%

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

Jalili

Aslibeiki

Varzaneh

et al. 2019

Beilstein J. Nanotechnol.

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Recent advances in the field of magnetic materials emphasize that the development of new and useful magnetic nanoparticles (NPs) requires an accurate and fundamental understanding of their collective magnetic behavior. Studies show that the magnetic properties are strongly affected by the magnetic anisotropy of NPs and by interparticle interactions that are the result of the collective magnetic behavior of NPs. Here we study these effects in more detail. For this purpose, we prepared Co x Fe3− x O4 NPs, with x = 0–1 in steps of 0.2, from soft magnetic (Fe3O4) to hard magnetic (CoFe2O4) ferrite, with a significant variation of the magnetic anisotropy. The phase purity and the formation of crystalline NPs with a spinel structure were confirmed through Rietveld refinement. The effect of Co doping on structure, morphology and magnetic properties of Co x Fe3− x O4 samples was investigated. In particular, we examined the interparticle interactions in the samples by δm graphs and Henkel plots that have not been reported before in literature. Finally, we studied the hyperthermia properties and observed that the heat efficiency of soft Fe3O4 is about 4 times larger than that of hard CoFe2O4 ferrite, which was attributed to the high coercive field of samples compared with the external field amplitude.

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“…When an antibiotic is combined with NPs, there are tendencies to occur synergetic effects against several bacterial infections, extending the drug-releasing at the therapeutic concentration for a long time. The NPs size and surface charge interact with the bacteria wall to promote their disruption or another pathway to inhibit cell proliferation (Rotello et al 2016;Gupta et al 2017;Jadhav et al 2018). Metallic silver, gold, zinc NPs are appreciated as antibacterial agents (Le Ouay and Stellacci 2015;Li et al 2016;Alahmadi et al 2017;Shankar and Rhim 2019), but their high cytotoxicity and low surface area characteristics require structural or chemical modifications to overcome these challenges (Seabra and Durán 2015).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of nanostructured mesoporous silica-coated magnetic nuclei with polyelectrolyte layers for tetracycline hydrochloride control release

et al. 2020

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Colloidal drug delivery systems are one of the most promising tools for the treatment of several diseases. We present a synthesis route based on four steps involving mesoporous silica-coated magnetite nanoparticles (MNPs) capped by polyelectrolyte (PE) assembling. The morphology and physical properties of the different components of the system were investigated. The magnetite phase of the iron oxide nanoparticles was identified by X-ray diffraction before their incorporation into the mesoporous silica matrix by a sol-gel process. A MCM-41-like organized hexagonal mesoporous (≈4.2 nm) structure was achieved, as ensured by the α S -plot model. Polyethylenimine PEI and sodium alginate (ALG) PE layer-by-layer capping were successfully performed by simple successive dispersions of nanoparticles in the PE solution bath. TEM images confirmed a well-organized structure, as also supported by DLS and XPS analyses, which present an increase in diameter size and distinct chemical surface composition after each step of the synthesis. The two successive coatings of the MNPs induced a significative decrease of the magnetic susceptibility but kept sufficient intensity for drug delivery assisted by an external magnetic field. To validate the system as drug delivery, in vitro tetracycline hydrochloride (TCH) loading and release studies were performed in PBS solution for 48 h. It was found that the TCH-loaded uncapped mesoporous silica NPs released more than 90% of TCH after 48 h. Meanwhile, when capped by the PEs, only 30% of the total drug amount was released, due to a hindrance of the drug diffusion by the PE layer. The present work suggests that the combination of the low cost and non-toxic hybrid system proposed has potential use in nanomedicine as a drug delivery vehicle.

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Induction heating and in vitro cytotoxicity studies of MnZnFe2O4 nanoparticles for self-controlled magnetic particle hyperthermia

Cited by 50 publications

References 47 publications

Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

Synthesis of nanostructured mesoporous silica-coated magnetic nuclei with polyelectrolyte layers for tetracycline hydrochloride control release

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