Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component

Abstract

clinicaltrials.gov identifier: NCT00635154.

Role of Interleukin-1 in Radiation-Induced Cardiomyopathy

“…Whether IL-1-targeted strategies will be tolerated in patients receiving irradiation for cancer or whether such strategies will interfere with the cancer-killing properties of the irradiation is unknown and will require further study. Of interest, several studies are exploring IL-1-targeted strategies as cancer-treating strategies, and as such, IL-1 blockade may prove to serve a dual function of cardiac protection and cancer treatment (58)(59)(60).…”

The NLRP3 inflammasome, a target for therapy in diverse disease states

“…Myeloma is often treated with thalidomide, and this agent has recently been shown to inhibit caspase-1 activity (and IL-1b secretion) in keratinocytes [37]. This suggests that thalidomide, might act in myeloma via caspase-1 inhibition and the breaking of the IL-1b-IL-6 loop, targeted by Lust et al [36]. Furthermore, these studies suggest that targeting the action of IL-1b (e.g.…”

“…In myeloma, a plasma cell neoplasia localised to the bone marrow, there is a evidence that myeloma-derived IL-1b induces IL-6 production by bone marrow stromal cells, and this acts as a growth factor for proliferation of the myeloma cells. Blocking IL-1b with anakinra diminishes IL-6 production and, in a clinical trial, this treatment significantly reduced disease progression [36]. Myeloma is often treated with thalidomide, and this agent has recently been shown to inhibit caspase-1 activity (and IL-1b secretion) in keratinocytes [37].…”

“…The link between inflammation and cancer has prompted the evaluation of IL-1 production by tumour cells induces IL-6 that acts as a growth factor for myeloma cell proliferation [36] Eur. J.…”

The High Cost of Cancer Drugs and What We Can Do About It

“…Mayo Clinic Proceedings has published numerous articles highlighting the current treatment of cancer. [13][14][15][16][17] Most cancers are not curable, and most approved cancer drugs work only for a limited time. When one treatment fails, the patient will be treated with subsequent agents until all options are exhausted.…”