Induction of a homologous and heterologous invasion–inhibition effect after administration of Salmonella strains to newly hatched chicks

Methner, Ulrich; Barrow, Paul; Berndt, Angela

doi:10.1016/j.vaccine.2010.08.050

Cited by 19 publications

(7 citation statements)

References 22 publications

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“…Protective cross-reactive immunity against Salmonella strains has been demonstrated against both homologous and heterologous challenges (Beal et al , 2006), although cross-serogroup protection was not strong. Furthermore, a recent study reported that pre-treatment of newly hatched chickens with different Salmonella strains could produce a complete invasion–inhibition effect on any subsequent exposure to both homologous and heterologous strains (Methner et al , 2010). Pre-exposure with a highly invasive form of Salmonella Enteritidis caused a large influx of heterophils to the caecal mucosa in 1-day-old chicks, and subsequent heterologous caecal colonization was inhibited for a period of 48 h (Methner et al , 2010).…”

Section: Effects Of Prior Immunological Exposure To Vectors – Bacterimentioning

confidence: 99%

“…Furthermore, a recent study reported that pre-treatment of newly hatched chickens with different Salmonella strains could produce a complete invasion–inhibition effect on any subsequent exposure to both homologous and heterologous strains (Methner et al , 2010). Pre-exposure with a highly invasive form of Salmonella Enteritidis caused a large influx of heterophils to the caecal mucosa in 1-day-old chicks, and subsequent heterologous caecal colonization was inhibited for a period of 48 h (Methner et al , 2010). The implications of this kind of colonization-inhibition study on the immunological status of the affected chickens are yet to be fully elucidated.…”

Section: Effects Of Prior Immunological Exposure To Vectors – Bacterimentioning

confidence: 99%

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Pre-existing immunity against vaccine vectors – friend or foe?

et al. 2013

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Over the last century, the successful attenuation of multiple bacterial and viral pathogens has led to an effective, robust and safe form of vaccination. Recently, these vaccines have been evaluated as delivery vectors for heterologous antigens, as a means of simultaneous vaccination against two pathogens. The general consensus from published studies is that these vaccine vectors have the potential to be both safe and efficacious. However, some of the commonly employed vectors, for example Salmonella and adenovirus, often have pre-existing immune responses in the host and this has the potential to modify the subsequent immune response to a vectored antigen. This review examines the literature on this topic, and concludes that for bacterial vectors there can in fact, in some cases, be an enhancement in immunogenicity, typically humoral, while for viral vectors pre-existing immunity is a hindrance for subsequent induction of cell-mediated responses.

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Section: Effects Of Prior Immunological Exposure To Vectors – Bacterimentioning

confidence: 99%

Section: Effects Of Prior Immunological Exposure To Vectors – Bacterimentioning

confidence: 99%

Pre-existing immunity against vaccine vectors – friend or foe?

et al. 2013

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“…We chose poultry as our model vertebrates, both to study whether Bdellovibrio had any effect on animal well-being and also because this is a well-studied model used in Salmonella infection and intestinal/cecal colonization experiments (22,39,62), which would allow us to determine any therapeutic effects of Bdellovibrio treatment. The model of Salmonella in poultry was chosen for several additional reasons: first, and importantly for animal welfare, Salmonella enterica serovar Enteritidis often infects poultry, particularly laying hens, without clinical symptoms (13), unlike serovars such as Gallinarum, the agent responsible for fowl typhoid (11).…”

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confidence: 99%

Effects of Orally Administered Bdellovibrio bacteriovorus on the Well-Being and Salmonella Colonization of Young Chicks

Atterbury

Hobley

Till

et al. 2011

Appl Environ Microbiol

155

134

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Bdellovibrio bacteriovorus is a bacterium which preys upon and kills Gram-negative bacteria, including the zoonotic pathogens Escherichia coli and Salmonella. Bdellovibrio has potential as a biocontrol agent, but no reports of it being tested in living animals have been published, and no data on whether Bdellovibrio might spread between animals are available. In this study, we tried to fill this knowledge gap, using B. bacteriovorus HD100 doses in poultry with a normal gut microbiota or predosed with a colonizing Salmonella strain. In both cases, Bdellovibrio was dosed orally along with antacids. After dosing non-Salmonella-infected birds with Bdellovibrio, we measured the health and well-being of the birds and any changes in their gut pathology and culturable microbiota, finding that although a Bdellovibrio dose at 2 days of age altered the overall diversity of the natural gut microbiota in 28-day-old birds, there were no adverse effects on their growth and well-being. Drinking water and fecal matter from the pens in which the birds were housed as groups showed no contamination by Bdellovibrio after dosing. Predatory Bdellovibrio orally administered to birds that had been predosed with a gut-colonizing Salmonella enterica serovar Enteritidis phage type 4 strain (an important zoonotic pathogen) significantly reduced Salmonella numbers in bird gut cecal contents and reduced abnormal cecal morphology, indicating reduced cecal inflammation, compared to the ceca of the untreated controls or a nonpredatory ⌬pilA strain, suggesting that these effects were due to predatory action. This work is a first step to applying Bdellovibrio therapeutically for other animal, and possibly human, infections.

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“…The findings of the current study, together with previous data, may explain the dominance of S. Infantis in chicken meat. A study in which heterologous serovars of Salmonella were administrated to chicks at different intervals showed that the first strain to be inoculated inhibited the colonisation of the subsequent strains [ 9 ]. However, using simultaneous administration, we observed that the heterologous strains never inhibited each other in the inoculated chicks.…”

Section: Discussionmentioning

confidence: 99%

“…However, little is known about the issue. Several studies have administered multiple Salmonella serovars at different intervals (1 day or more) in an attempt to understand the dynamics of infection [ 8 , 9 ], but simultaneous administration of multiple Salmonella serovars is rare. Therefore, in the current study, we simultaneously infected 1-day-old chicks with S. Infantis and S. Typhimurium, and then housed the infected birds with non-infected chicks.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks

et al. 2017

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BackgroundTo confirm the hypothesis that Salmonella enterica subspecies enterica serovar (S.) Infantis has higher basic reproductive rates in chicks compared with other Salmonella serovars, 1-day-old specific-pathogen-free chicks (n = 8) were challenged simultaneously with S. Infantis and S. Typhimurium per os. Challenged chicks (Group A) were then housed with non-infected chicks (Group B, n = 4) for 6 days (from 2 to 8 days of age). Group B birds were then housed with other non-infected birds (Group C, n = 4), which were then transferred to cages containing a further group of untreated chicks (Group D, n = 2). A control group consisting of four non-infected chicks was used for comparison. All chickens were humanely sacrificed at 18 days of age, and Salmonella from bowel and liver samples were enumerated.ResultsBoth serovars were isolated from all groups except the control group. S. Typhimurium was isolated at a greater frequency than S. Infantis from the bowel samples of chicks from Groups B, C and D, while no differences in colonisation rates were observed between the two serovars in liver samples from Groups B, C and D. S. Typhimurium, but not S. Infantis, was immunohistochemically detected in the lamina propria of the cecum and rectum in five birds of Group A. Despite the competitive administration, neither of the two serovars completely excluded the other, and no differences were observed in basic reproductive rates between the two serovars.ConclusionsThese findings, together with data from previous studies, suggest that the initial quantitative domination of S. Infantis in chicken flocks may explain why this serovar is predominant in broiler chickens.

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Induction of a homologous and heterologous invasion–inhibition effect after administration of Salmonella strains to newly hatched chicks

Cited by 19 publications

References 22 publications

Pre-existing immunity against vaccine vectors – friend or foe?

Pre-existing immunity against vaccine vectors – friend or foe?

Effects of Orally Administered Bdellovibrio bacteriovorus on the Well-Being and Salmonella Colonization of Young Chicks

Simultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks

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