Induction of a protective response with an IgA monoclonal antibody against Mycobacterium tuberculosis 16kDa protein in a model of progressive pulmonary infection

López, Yamile Lira; Yero, Daniel; Falero-Díaz, Gustavo; Olivares, Nesty; Sarmiento, María E.; Sifontes, Sergio; Solís, Rosa L.; Barrios, Jorge A.; Aguilar, Diana; Hernández-Pando, Rogelio; Acosta, Armando

doi:10.1016/j.ijmm.2008.10.007

Cited by 69 publications

(51 citation statements)

References 24 publications

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“…At 21 days post-infection, pre-treatment of mice with TBA61 caused a significant decrease in viable bacteria in the lungs compared to control mice or those treated with the Mab against the 38-kDa protein (TBA84). Consistent with the reduction of viable bacteria following treatment with TBA61, the area of peribronchial inflammation was also statistically smaller in this group compared to the control group [60].…”

Section: Studies Performed With Monoclonal Antibodiessupporting

confidence: 71%

Towards a New Challenge in TB Control: Development of Antibody-Based Protection

Acosta¹,

López²,

Nor³

et al. 2012

Understanding Tuberculosis - Analyzing the Origin of Mycobacterium Tuberculosis Pathogenicity

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Section: Studies Performed With Monoclonal Antibodiessupporting

confidence: 71%

Towards a New Challenge in TB Control: Development of Antibody-Based Protection

Acosta¹,

López²,

Nor³

et al. 2012

Understanding Tuberculosis - Analyzing the Origin of Mycobacterium Tuberculosis Pathogenicity

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“…132 Passive immunization of Mtb-infected SCID mice with sera from mice treated with Mtb extracts also reduced the number of bacilli in the lungs and the extent of granulomatous infiltration. 88 Treatment with antibodies specific for particular Mtb components, such as 19-kDa lipoprotein, 130 a-crystallin, 217 and LAM, 93 resulted in reduction of bacterial load and lesions in the lungs of infected mice. Antibody-opsonized mycobacteria are more efficiently internalized and killed by neutrophils and macrophages 49 and more effectively processed for antigen presentation by DCs.…”

mentioning

confidence: 99%

The Pathology of Mycobacterium tuberculosis Infection

Sakamoto

2012

Vet Pathol

123

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Mycobacterium tuberculosis is an old enemy of the human race, with evidence of infection observed as early as 5000 years ago. Although more host-restricted than Mycobacterium bovis, which can infect all warm-blooded vertebrates, M. tuberculosis can infect, and cause morbidity and mortality in, several veterinary species as well. As M. tuberculosis is one of the earliest described bacterial pathogens, the literature describing this organism is vast and overwhelming. This review strives to distill what is currently known about this bacterium and the disease it causes for the veterinary pathologist.

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“…First, IgA reactivity was restricted by antigen components. To our knowledge, only a few well-defined subsets of mycobacterial antigens can elicit an IgA response [39,40]. Second, it has been documented that IgA provides protection from early tuberculous pulmonary infection and that the protection is of short duration [41].…”

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confidence: 99%

B lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis

Feng

Liu

et al. 2011

Eur J Immunol

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B-cell biology has been largely uncharacterized in the field of tuberculosis (TB). In this study, we investigated the immunophenotypical and functional characteristics of B cells obtained from the pleural fluid (PF) and peripheral blood of patients with tuberculous pleuritis (TP). Our results indicated that the total numbers of B cells, CD271 memory B cells and plasmablasts were clearly lower in the PF than in peripheral blood. Furthermore, we found significantly higher expression of CXCR4 on B cells in the PF, and a chemotaxis assay showed that B cells in the PF were more responsive to stromal cell-derived factor-1 (SDF-1) than B cells from peripheral blood. In addition, SDF-1 levels in PF were remarkably high compared with SDF-1 levels in plasma, suggesting that the SDF-1/CXCR4 axis might facilitate the migration of circulating B cells into tuberculous pleural space. Importantly, we observed that significantly more antibodies were produced by B cells in the PF following stimulation with BCG, early secretory antigenic target (ESAT-6)/culture filtrate protein-10 (CFP-10) or ESAT-6 protein.Collectively, these data demonstrate that Mycobacterium tuberculosis-specific B cells exist at local sites of infection in TP patients and this localization might influence the immune response to M. tuberculosis. Key words: B cells . Chemokine receptors . Immune responses . Tuberculous pleuritis Supporting Information available onlineIntroduction Tuberculosis (TB), one of the oldest infectious diseases associated with humans, is a chronic disease caused by infection with Mycobacterium tuberculosis [1,2]. The incidence of TB has increased during the past 20 years for reasons such as insufficient prevention efforts, incorrectly prescribed medication, the emergence of drug-resistant strains of M. tuberculosis and the prevalence of human immunodeficiency virus (HIV) infection [3,4]. Traditionally, the immune response against M. tuberculosis infection is dominated by cell-mediated immunity (CMI), which relies primarily on CD4 1 and CD8 1 T cells. Therefore, many studies have been conducted in an attempt to augment cellular immunity, with an aim to develop new vaccine candidates against TB [5][6][7]. In contrast to these investigations, the contribution of B cells and humoral immunity in the TB field remains largely unexamined and elusive. Fewer efforts to promote an effective humoral response against M. tuberculosis have been made compared with those devised to elicit a cellular response [8]. However, it is worth noting that any successful, novel vaccine strategy against TB will have to properly invoke both humoral and cellular immunity, given that these responses are the two critical arms of adaptive immunity and always collaborate to repel infectious pathogens [9]. Numerous murine studies have shown that B cells and antibodies have pleiotropic activities and display previously underappreciated roles during M. tuberculosis infection [10][11][12]. In contrast to the murine studies, there are limited data regarding any phenotypic and...

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Induction of a protective response with an IgA monoclonal antibody against Mycobacterium tuberculosis 16kDa protein in a model of progressive pulmonary infection

Cited by 69 publications

References 24 publications

Towards a New Challenge in TB Control: Development of Antibody-Based Protection

Towards a New Challenge in TB Control: Development of Antibody-Based Protection

The Pathology of Mycobacterium tuberculosis Infection

B lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis

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