Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating

Georgiev, Plamen; Bostedt, H.; Goericke-Pesch, Sandra; Dimitrov, Milen; Petkov, P.; Stojanthev, K; Tsoneva, Vanya; Wehrend, Axel

doi:10.1111/j.1439-0531.2009.01540.x

Cited by 11 publications

(14 citation statements)

References 21 publications

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“…When used on days 5 or 6 after mating, 14 the pregnancy termination rate is 100%; the success rate then gradually declines as gestation progresses, with a ratio of 87.0-88.5% to 100% between days 21 and 25, 5,12,13 and finally down to a 66.7% success rate on days 45 and 46. 40 According to Scott, 41 an ovariectomy after day 45 of gestation does not disrupt pregnancies in cats, and after day 30 of gestation the placental P4 becomes more important than the luteal P4 for the maintenance of pregnancy. 42 This physiological property could explain the lower pregnancy termination rate (71.5%) in the AGL group in this study compared with the aforementioned studies, 5,[12][13][14] which were performed in the early days of gestation.…”

Section: Clinical Findingsmentioning

confidence: 99%

Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Aslan

Önyay

et al. 2018

Journal of Feline Medicine and Surgery

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Objectives This study aimed to determine the efficacy and safety of oral misoprostol (MIS) administration in the induction of mid-term pregnancy termination in cats. Methods Twenty-eight cats that were pregnant for 30-40 days were allocated to four groups. The aglepristone (AGL) group (n = 7) received 10 mg/kg SC aglepristone q24h for two consecutive days. In the AGL+MIS group (n = 7), AGL (as administered in the AGL group) and MIS (200 µg/cat PO q12h until the start of abortion) were administered. The MIS200 (n = 7) and MIS400 groups (n = 7) received MIS (200 or 400 µg/cat misoprostol, respectively) alone PO q12h until the start of abortion. Blood samples were collected at the start of treatment (d0), 4 days after the start of treatment (d4) and on the day of complete abortion/end of administration (dA/d7). Results The efficacy of the treatment was 71.4% in the AGL group, 100% in the AGL+MIS group, 0% in MIS200 group and 57.4% in MIS400 group ( P = 0.004). No significance was found in relation to the interval from treatment to the start/end of abortion and the duration of abortion in all groups. The most observed side effect was vomiting in both groups administered MIS, particularly in the MIS400 group (56.7%). Progesterone (P4) concentrations were reduced during the abortion, but not to basal levels, in all groups. P4 concentrations were significantly lower at dA/d7 in the MIS400 group compared with the AGL and AGL+MIS groups ( P = 0.002). Conclusions and relevance The results obtained from this study showed that low doses of MIS do not induce abortions in cats but increase the effect of AGL. Although higher doses could terminate pregnancies, this also causes intense unwanted side effects. Therefore, the use of MIS alone as an abortifacient in cats is not recommended. For mid-term pregnancy termination in cats, the combination of misoprostol and aglepristone provides a more effective abortifacient than using either of them alone.

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Section: Clinical Findingsmentioning

confidence: 99%

Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Aslan

Önyay

et al. 2018

Journal of Feline Medicine and Surgery

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“…Another alternative to induce abortion is the use of antiprogestins, such as aglepristone (ALI). Treatment with ALI has been proven to be safe and effective for early, middle, and late pregnancy termination in the queen [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy

et al. 2017

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Progesterone (P) is a requirement for pregnancy development. Previous reports observed a maximal value of serum P concentration on 21 days after the first mating after which it slowly declines throughout the rest of pregnancy. Ultrasound examination should be performed to ensure that pregnancy interruption is complete. Limited information is available on the ultrasonic appearance of conceptuses during pregnancy termination in cats The objective was to study serum P concentration and ultrasonographic changes during aglepristone (ALI) or cloprostenol (CLO) treatment and to evaluate the fertility after treatment. Two experiments (EXP) were carried out to accomplish this aim. Sixty queens, 12- to 36-month-old, were used. On Days 21 to 22 of pregnancy (EXP I) or 35 to 38 of pregnancy (EXP II), queens were divided into three groups (G). Queens in G1 received ALI (10 mg/kg, sc; EXP I, n = 10; EXP II, n = 10) for 2 consecutive days. Queens in G2 received CLO (5 μg/kg, sc; EXP I, n = 10; EXP II = 10) for 3 consecutive days. Queens in G3 received 1 mL of saline solution (PLA, sc; EXP I, n = 10; EXP II = 10). Blood samples were taken before treatment (Day 0) and every day during 10 days after the treatment to measure serum P concentrations. Likewise, after treatment, queens were monitored daily by ultrasonography for 10 days and weekly until the end of gestation to obtain gestational sacs measurements (GS), fetal measurements, and fetal biophysical profile. Data were analyzed by ANOVA. Serum P concentrations were significantly different on Day 6 (EXP I) and on Day 1 (EXP II) in ALI and CLO groups compared with PLA group (P < 0.05 and P < 0.01; respectively). The ultrasonographic monitoring during treatment allowed assessing changes in the GS and fetal measurements, embryo-fetal viability, and risk of pregnancy loss. In conclusion, the results from this study reported changes in serum P concentration and in ultrasonography measurements during pregnancy interruption with ALI or CLO treatment. Also it was observed that ALI and CLO are safe drugs and can preserve posttreatment queen fertility. Therefore, the results obtained in our work will be applied in feline reproduction practice.

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“…AGL injected in pregnant queens on days 45 and 46 after mating terminated pregnancy in only 66.7% of cases. 16…”

Section: Introductionmentioning

confidence: 99%

Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens

Alkan

Tez

et al. 2019

Journal of Feline Medicine and Surgery

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Objectives Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy. Methods Pregnant queens were assigned to two groups. Queens in the AGL group (n = 10) received AGL 10 mg/kg, twice, 24 h apart. Queens in the AGL-CLO group (n = 9) were additionally injected with a single dose of CLO (5 μg/kg) 24 h after the second dose of AGL. Progesterone, 17beta(β)-oestradiol, cortisol, oxytocin and prostaglandin F2alpha (PGF2α) metabolite were measured in sera obtained at days 0, 1 and 2, and on the day of abortion. Results Average gestational age in both groups was similar (AGL 38.61 ± 0.91 days vs AGL-CLO 39.39 ± 1.35 days; P >0.05). Termination rates were 80% and 100% in the AGL and AGL-CLO groups, respectively ( P <0.05). Fetal expulsion time was significantly longer ( P <0.001) in the AGL group (96.9 ± 6 h) compared with the AGL-CLO group (69.8 ± 3.3 h). Duration of abortion was 19.8 ± 2.6 h and 12.6 ± 1.4 h in the AGL and AGL-CLO groups, respectively ( P <0.05). Both treatments were well tolerated. Significantly ( P <0.05) lower serum progesterone concentrations were observed in both groups at the day of abortion and concentrations in the AGL-CLO group (4.19 ± 0.80 ng/ml) were lower than in the AGL group (9.89 ± 2.21 ng/ml; P <0.05). Conclusions and relevance AGL and CLO combination increases pregnancy termination rate in late-term pregnant queens. In addition, CLO contributes to a decrease in luteal function in AGL-treated late-term pregnant queens.

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Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating

Cited by 11 publications

References 21 publications

Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy

Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens

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