Induction of ALDH Activity in Intestinal Dendritic Cells by<i>Lactobacillus plantarum</i>NRIC0380

Yoshida, Tadashi; Enomoto, Mai; Nakayama, Sayuri; Adachi, Yu; Fujiwara, Wataru; Sugiyama, Hisashi; Shimojoh, Manabu; Okada, Sanae; Hattori, Makoto

doi:10.1271/bbb.130144

Cited by 9 publications

(13 citation statements)

References 36 publications

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“…RA produced by intestinal DCs also aids in Treg cell function by inducing the gut‐homing receptors CCR9 and integrin α 4 β 7 on T cells, which in turn induces gut‐homing Treg cells able to migrate to the intestine to suppress immune responses to intestinal antigens . ALDH produced by intestinal DCs also appears to be important in the intestinal immune tolerance induced by bacteria such as Lactobacillus planatarum , an intestinal bacterium known to have anti‐allergenic and anti‐inflammatory effects . In vitro and in vivo studies show induction of Treg cells by L. planatarum through RA‐ and TGF‐ β ‐mediated intestinal DC stimulation …”

Section: Aldh In Treg Induction and Functionmentioning

confidence: 99%

“…ALDH produced by intestinal DCs also appears to be important in the intestinal immune tolerance induced by bacteria such as Lactobacillus planatarum , an intestinal bacterium known to have anti‐allergenic and anti‐inflammatory effects . In vitro and in vivo studies show induction of Treg cells by L. planatarum through RA‐ and TGF‐ β ‐mediated intestinal DC stimulation …”

Section: Aldh In Treg Induction and Functionmentioning

confidence: 99%

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Aldehyde dehydrogenase in regulatory T‐cell development, immunity and cancer

et al. 2018

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The role of aldehyde dehydrogenase (ALDH) in carcinogenesis and resistance to cancer therapies is well known. Mounting evidence also suggests a potentially important role for ALDH in the induction and function of regulatory T (Treg) cells. Treg cells are important cells of the immune system involved in promoting immune tolerance and preventing aberrant immune responses to beneficial or non-harmful antigens. However, Treg cells also impair tumor immunity, leading to the progression of various carcinomas. ALDH expression and the subsequent production of retinoic acid by numerous cells, including dendritic cells, macrophages, eosinophils and epithelial cells, seems important in Treg induction and function in multiple organ systems. This is particularly evident in the gastrointestinal tract, pulmonary tract and skin, which are exposed to a myriad of environmental antigens and represent interfaces between the human body and the outside world. Expression of ALDH in Treg cells themselves may also be involved in the proliferation of these cells and resistance to certain cytotoxic therapies. Hence, inhibition of ALDH expression may be useful to treat cancer. Besides the direct effect of ALDH inhibition on carcinogenesis and resistance to cancer therapies, inhibition of ALDH could potentially augment the immune response to tumor antigens by inhibiting Treg induction, function and ability to promote immune tolerance to tumor cells in multiple cancer types.

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Section: Aldh In Treg Induction and Functionmentioning

confidence: 99%

Section: Aldh In Treg Induction and Functionmentioning

confidence: 99%

Aldehyde dehydrogenase in regulatory T‐cell development, immunity and cancer

et al. 2018

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“…Various mechanisms have been demonstrated in animal and cellular models [9][10][11][12][13][14][15][16][17][18][19][20][21][22] . It is necessary to elucidate the difference of species and strains for a better understanding.…”

Section: Resultsmentioning

confidence: 99%

“…Retinoic acid, a vitamin A metabolite has activity to induce Foxp3 + regulatory T cells. The induction of RALDH2 activity, a key enzyme in the production of retinoic acid, is an interesting mechanism of regulatory T cell induction 15) . A strain of L. plantarum has been shown to induce ALDH activity in MLN dendritic cells and induce Foxp3 + regulatory T cells in mice 14,15) .…”

Section: Mechanisms Of Inhibition Of Allergy By Lab and Other Probiotmentioning

confidence: 99%

“…The induction of RALDH2 activity, a key enzyme in the production of retinoic acid, is an interesting mechanism of regulatory T cell induction 15) . A strain of L. plantarum has been shown to induce ALDH activity in MLN dendritic cells and induce Foxp3 + regulatory T cells in mice 14,15) . We have shown a yet another mechanism for Bifidobacterium to inhibit Th2 response, being the inhibition of Th2 chemokines 16) .…”

Section: Mechanisms Of Inhibition Of Allergy By Lab and Other Probiotmentioning

confidence: 99%

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Regulation of allergy by probiotics

Hachimura

2015

Inflammation and Regeneration

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A considerable number of reports show that administration of probiotics may prevent or alleviate allergy. These may be direct effects of bacterial components on immune system, or through indirect effects through alteration of intestinal microbiota. Animal and cellular studies imply that direct effects may be through inhibition of Th2 responses by enhancement of Th1 response, induction of apoptosis, induction of regulatory T cells, and other mechanisms. One mechanism of the indirect effects may be regulatory T cell induction by metabolites of microbiota. Further studies are required to fully understand the mechanisms. Rec.2/13/2015, Acc.4/14/2015, pp137-139

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