1980
DOI: 10.1093/bja/52.8.803
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Induction of Anaesthesia With Etomidate: Haemodynamic Study of 36 Patients

Abstract: The haemodynamic effects of anaesthetic induction with i.v. etomidate have been assessed in 36 patients. The variables studied were recorded under basal conditions and 3 and 10 min after induction, before surgical stimulus. There was a reduction in cardiac output, stroke volume and arterial pressure, and a compensating increase in heart rate. Pulmonary arterial pressure and vascular resistance, central venous pressure and pulmonary capillary wedge pressure were virtually unchanged. Although etomidate has a neg… Show more

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Cited by 113 publications
(36 citation statements)
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“…'~ found a reduction in peak tension development and postulated a dose-dependent negative inotropism for etomidate. A decrease in mean arterial pressure, together with a reduction in cardiac output without alteration of peripheral resistance, was described by Criado et al 39 This was taken to signify a negative inotropic effect of etomidate, and a reduction of left ventricular dpldt with unchanged filling pressures has also been A minor degree of negative inotropism was therefore disc~ssed.~' In contrast we were unable to demonstrate a negative inotropic action of etomidate; whether this is solely a problem of dose cannot be answered with certainty.…”
Section: A Gauss H Heinrich and Ohg Wilder-smithmentioning
confidence: 75%
“…'~ found a reduction in peak tension development and postulated a dose-dependent negative inotropism for etomidate. A decrease in mean arterial pressure, together with a reduction in cardiac output without alteration of peripheral resistance, was described by Criado et al 39 This was taken to signify a negative inotropic effect of etomidate, and a reduction of left ventricular dpldt with unchanged filling pressures has also been A minor degree of negative inotropism was therefore disc~ssed.~' In contrast we were unable to demonstrate a negative inotropic action of etomidate; whether this is solely a problem of dose cannot be answered with certainty.…”
Section: A Gauss H Heinrich and Ohg Wilder-smithmentioning
confidence: 75%
“…13 It has a very stable cardiovascular profile [14][15][16][17] and has been recently reintroduced in India as an induction agent. Due to absence of any study using etomidate in Indian setting, we conducted a study to evaluate the hemodynamic effects of etomidate in comparison to those of thiopentone and propofol during induction of general anaesthesia.…”
Section: Discussionmentioning
confidence: 99%
“…TOMIDATE has only a minimal effect on cardiovascular function, and it has been used for anesthetizing patients whose hemodynamic stability must be maintained. 1 An induction dose of 0.3 mg·kg -1 of etomidate, when given to cardiac patients for noncardiac surgery, results in almost no hemodynamic change. 2 For patients with mitral or aortic valvular disease, etomidate produces a modest decrease in the mean arterial pressure.…”
Section: Discussionmentioning
confidence: 99%