Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor

Lobb, Roy R.; Alderman, Edward M.; Fett, James W.

doi:10.1021/bi00340a001

Cited by 175 publications

(53 citation statements)

References 38 publications

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“…Binds to its receptor FGFR Stimulates in vitro and in vivo angiogenesis 92,145,417 Stimulates endothelial cell proliferation 148 Enhances endothelial cell migration 145,149 Stimulates the production of matrix proteases in endothelial cells 147 …”

Section: Fgf Fibroblast Growth Factormentioning

confidence: 99%

The Role of Mechanical Stresses in Angiogenesis

Shiu

Weiss

Hoying

et al. 2005

Crit Rev Biomed Eng

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ABSTRACT:Angiogenesis is the formation of new capillary blood vessels from preexisting vessels. It is involved in many normal and diseased conditions, as well as in the application of tissue-engineered products. Th ere has been extensive eff ort made to develop strategies for controlling pathological angiogenesis and for promoting vascularization in biomedical engineering applications. Central to advancing these strategies is a mechanistic understanding of the angiogenic process. Angiogenesis is tightly regulated by local tissue environmental factors, including soluble molecules, extracellular matrices, cell-cell interactions, and diverse mechanical forces. Great advances have been made in identifying the biochemical factors and intracellular signaling pathways that mediate the control of angiogenesis. Th is review focuses on work that explores the biophysical aspect of angiogenesis regulation. Specifi cally, we discuss the role of cell-generated forces, counterforces from the extracellular matrix, and mechanical forces associated with blood fl ow and extravascular tissue activity in the regulation of angiogenesis. Because angiogenesis occurs in a mechanically dynamic environment, future investigations should aim at understanding how cells integrate chemical and mechanical signals so that a rational approach to controlling angiogenesis will become possible. In this regard, computational models that incorporate multiple epigenetic factors to predict capillary patterning will be useful.

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Section: Fgf Fibroblast Growth Factormentioning

confidence: 99%

The Role of Mechanical Stresses in Angiogenesis

Shiu

Weiss

Hoying

et al. 2005

Crit Rev Biomed Eng

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“…bFGF is also angiogenic in several models [12,13]. Considerable interest has therefore developed as to its possible role in proliferative diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Characterization of release of basic fibroblast growth factor from bovine retinal endothelial cells in monolayer cultures

Brooks

Burrin

Kohner

1991

Biochemical Journal

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Release of basic fibroblast growth factor (bFGF) was investigated in bovine retinal endothelial cells (BREC) maintained in monolayer culture. Confluent cells released bFGF into serum-free culture medium or medium containing 5 % serum at rates of up to 105.2 and 61.3 pM/day respectively. bFGF release coincided with a decrease in monolayer cell number and increases in lactate dehydrogenase (LDH) concentration and cells and cell-debris particles in the medium, which suggested that cell damage and lysis were responsible for growth-factor release. Maximum bFGF release at 24 h (230+10 pM) occurred when the cells were treated with lipopolysaccharide (10 /eg/ml), which also produced the greatest changes in parameters of cell damage. Sub-confluent cells showed little overt damage at 24 h, but released bFGF (78 + 20 pM) along with LDH, indicating that some cell lysis had occurred. Insulin-like growth factor 1 (IGF-1) was also released into serum-free culture medium at a rate of 0.34 nM/day, but not into medium containing serum or when the cells were treated with lipopolysaccharide. This implies that the mechanism of IGF-1 release is different from that of bFGF and is not related to cell damage. Culture medium conditioned by BREC stimulated the proliferation of these cells, as measured by an increase in their incorporation of [methyl-3H]

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“…Mitogenicity of FGFs towards vascular endothelial cells also accounts for the potent angiogenic activity of these factors (9,19,34). FGFs were originally detected and purified from extracts of whole tissues, most notably from the brain and pituitary gland (5,20,33).…”

mentioning

confidence: 99%

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

Zhan¹,

Bates²,

Hu³

et al. 1988

Mol. Cell. Biol.

388

180

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We previously described the isolation of a human oncogene which had acquired transforming potential by a DNA rearrangement accompanying transfection of NIH 3T3 cells with human tumor DNA (X. Zhan, A. Culpepper, M. Reddy, J. Loveless, and M. Goldfarb, Oncogene 1:369-376, 1987). We now term this oncogene the FGF-5 gene, since it specifies the fifth documented protein related to fibroblast growth factors (FGFs. Two regions of the FGF-5 sequence, containing 122 of its 267 amino acid residues, were 40 to 50% homologous to the sequences of acidic and basic FGFs as well as to the sequences of the FGF-related oncoproteins int-2 and hst/KS3. The FGF-5 gene bears the three exon structures typical for members of this family. FGF-5 was found to be expressed in the neonatal brain and in 3 of the 13 human tumor cell lines examined. Several experiments strongly suggested that FGF-5 is a growth factor with properties common to those of acidic and basic FGFs. The rearrangement which activated the FGF-5 gene during DNA transfection had juxtaposed a retrovirus transcriptional enhancer just upstream from the native promoter of the gene.

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Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor

Cited by 175 publications

References 38 publications

The Role of Mechanical Stresses in Angiogenesis

The Role of Mechanical Stresses in Angiogenesis

Characterization of release of basic fibroblast growth factor from bovine retinal endothelial cells in monolayer cultures

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

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