Induction of Anti-inflammatory Responses by DietaryMomordica charantiaL. (Bitter Gourd)

Manabe, Masaru; Takenaka, Ryo; Nakasa, Teruko; Okinaka, Osamu

doi:10.1271/bbb.67.2512

Cited by 45 publications

(24 citation statements)

References 25 publications

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“…It was recently that it was able to act on a similar way as insulin, with the only difference that insulin stops the use of fats as energy source by inhibiti of glucagons and bitter melon inhibits key carbohydrate hydrolyzing enzymes a> α α-glucosidase (Mahomoodally et al, clinical conditions where Momordica charantia some potential include; dyslipidemia, microbial infection and potentially as a cytotoxic agent for certain types of cancer (Pitchakarn, 2012). Another research indicates Momordica charantia modify the immune response in cancer patients via decreased intestinal secretion of interleukin reduced lymphotcyte number and increase T and natural killer cell population (Manabe 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of oral administration of Momordica charantia on haematological parameters of adult albino rats

Umar¹

2018

Bayero J. Pure App. Sci.

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The aim of the study was to evaluate the haematological parameters of adult albino rats following oral administration of extract of Momordica charantia. according to their body weights (270±30g). The Group A (control) group was administered orally with distilled water daily for six (6) weeks. Group B, C and D were administered orally with 125 mg, 250mg and 500mg of the extract for six (6) weeks respectively. The rats were humanely sacrificed, blood sample collected was from the heart of the rats, for haematological (red blood cell, white blood cell, hemoglobin, lymphocytes, eosinophil and neutrophils counts) analys of variance was used to compare the mean of haematological parameters. It was observed that Momordica charantia elevate the white blood cell count when compared to the control group. It was also observed that the red blood cell count o Momordica charantia showed no change in value when compared to the control group. There was increase in lymphocytes and eosinophil count across the groups treated with methanolic extract. Conclusion: The Momordica charantia has potential in elevating some of the haematological parameters of the treated adult albino rats

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Section: Introductionmentioning

confidence: 99%

Effects of oral administration of Momordica charantia on haematological parameters of adult albino rats

Umar¹

2018

Bayero J. Pure App. Sci.

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“…The unripe fruit has also been used in developing countries as traditional medicine for microbial infections, sluggish digestion and intestinal gas, inflammation, fever reduction, and wound healing [31]. Recent studies on its pharmacological properties have shown several biological activities of bitter melon, including antidiabetic, antilipidemic, antibacterial, antiviral and anticancer activities [32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp

et al. 2009

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Hepatocyte growth factor (HGF) is useful as a potential therapeutic agent for hepatic and renal fibrosis and cardiovascular diseases through inducing proliferation of epithelial and endothelial cells. HGF inducers may also be useful as therapeutic agents for these diseases. However, there have been no reports on induction of HGF production by plant extracts or juices. An extract of bitter melon (Momordica charantia L.) pulp markedly induced HGF production. There was a time lag of 72 h before induction of HGF production after the extract addition. Its stimulatory effect was accompanied by upregulation of HGF gene expression. Increases in mitogen-activated protein kinases (MAPKs) were observed from 72 h after the extract addition. Inhibitors of MAPKs suppressed the extract-induced HGF production. The extract also stimulated cell proliferation.Both activities for induction of HGF production and cell proliferation were eluted together in a single peak with 14 000 Da on gel filtration. The results indicate that bitter melon pulp extract induced HGF production and cell proliferation of human dermal fibroblasts and suggest that activation of MAPKs is involved in the HGF induction. Our findings suggest potential usefulness of the extract for tissue regeneration and provide an insight into the molecular mechanism underlying the wound-healing property of bitter melon.

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“…It may modulate anti-inflammatory cytokines, as studies show that the pulp upregulates interferon-γ in mice, 7 and transforming growth factor-β and interleukin-10 in vitro. 8 It has been shown to have anti-staphylococcal activity in vitro. 9 It may also improve skin barrier function through effects on peroxisome proliferatoractivated receptor-delta, 10 which is emerging as a player in epidermal barrier homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Complementary use of topical bitter melon for atopic dermatitis

et al. 2012

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Momordica charantia (bitter melon) is popular in systems of traditional medicine to treat a variety of diseases including atopic dermatitis, which is an inflammatory, chronically relapsing skin disorder characterized by dry, scaly, pruritic skin. While there is growing community interest in adopting bitter melon as a complementary medicine, there are no clinical studies looking at its use for atopic dermatitis. Here we report a case of a 6-yearold female with severe refractory atopic dermatitis that responded to treatment with topical bitter melon in an open half-side comparison trial.

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Induction of Anti-inflammatory Responses by DietaryMomordica charantiaL. (Bitter Gourd)

Cited by 45 publications

References 25 publications

Effects of oral administration of <i>Momordica charantia</i> on haematological parameters of adult albino rats

Effects of oral administration of <i>Momordica charantia</i> on haematological parameters of adult albino rats

Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp

Complementary use of topical bitter melon for atopic dermatitis

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