Induction of anti‐secretory factor in human milk may prevent mastitis

Svensson, Kristin; Lange, Stefan; Lönnroth, Ivar; Widström, Ann‐Marie; Hanson, L Å

doi:10.1111/j.1651-2227.2004.tb02754.x

Cited by 23 publications

(18 citation statements)

References 77 publications

(107 reference statements)

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“…It appears in human milk and has been shown in a placebo-controlled study to prevent clinical mastitis (Svensson et al 2004). In a double-blind placebo-controlled study of acute or prolonged diarrhoea in 240 Pakistani children (Zaman et al 2007) it was found to be protective.…”

Section: Anti-secretory Factormentioning

confidence: 99%

“…The human peptide anti-secretory factor, which can be induced in human milk (Svensson et al 2004), has recently been shown to give protection against acute diarrhoea as well as prolonged diarrhoea (Zaman et al 2007). A Mexican study ) has shown that breast-feeding is associated with a 5-fold lower risk of diarrhoea caused by G. lamblia compared with no breast-feeding, and a 1 .…”

Section: Breast-feeding and Diarrhoeamentioning

confidence: 99%

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Session 1: Feeding and infant development Breast-feeding and immune function

2007

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The newborn receives, via the placenta, maternal IgG antibodies against the microbes present in its surroundings, but such antibodies have a pro-inflammatory action, initiating the complement system and phagocytes. Although the host defence mechanisms of the neonate that involve inflammatory reactivity are somewhat inefficient, this defence system can still have catabolic effects. Breast-feeding compensates for this relative inefficiency of host defence in the neonate by providing considerable amounts of secretory IgA antibodies directed particularly against the microbial flora of the mother and her environment. These antibodies bind the microbes that are appearing on the infant's mucosal membranes, preventing activation of the pro-inflammatory defence. The major milk protein lactoferrin can destroy microbes and reduce inflammatory responses. The non-absorbed milk oligosaccharides block attachment of microbes to the infant's mucosae, preventing infections. The milk may contain anti-secretory factor, which is anti-inflammatory, preventing mastitis in mothers and diarrhoea in infants. Numerous additional factors in the milk are of unknown function, although IL-7 is linked to the larger size of the thymus and the enhanced development of intestinal Tgd lymphocytes in breast-fed compared with non-breast-fed infants. Several additional components in the milk may help to explain why breast-feeding can reduce infant mortality, protecting against neonatal septicaemia and meningitis. It is therefore important to start breast-feeding immediately. Protection is also apparent against diarrhoea, respiratory infections and otitis media. There may be protection against urinary tract infections and necrotizing enterocolitis, and possibly also against allergy and certain other immunological diseases, and tumours. In conclusion, breast-feeding provides a very broad multifactorial anti-inflammatory defence for the infant.

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Section: Anti-secretory Factormentioning

confidence: 99%

Section: Breast-feeding and Diarrhoeamentioning

confidence: 99%

Session 1: Feeding and infant development Breast-feeding and immune function

2007

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“…It is present in most human tissues, and it is especially rich in fluid‐transporting epithelia, certain endocrine cells, neurons and immune cells. Intestinal exposure to bacterial toxins or intake of specific dietary compounds have proved to enhance the anti‐secretory and anti‐inflammatory activity of endogenous AF and induction of AF in humans have proved to prevent mastitis . Whether the mother's AF levels may influence oral colonisation of the infant is unexplored.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of oral Candida in the first year of life

Stecksén‐Blicks

Granström

Silfverdal

et al. 2015

Mycoses

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Colonisation of the gastrointestinal tract is influenced by primary microbial exposure and bioactive factors in breastmilk. The aim was to explore the prevalence of oral Candida in the first year of life in relation to selected exposures. Oral Candida was studied in 100 healthy infants at 4 and 8 weeks, 3, 6 and 12 months of age and related to delivery mode, birth weight, infant health and feeding, antibiotics, antimycotics, steroids and probiotics in mother and infant, living conditions, maternal smoking and infections The association between lactoferrin and antisecretory factor in breastmilk and maternal serum haemoglobin, transferrin, and ferritin levels in relation to oral Candida was also explored. About 11% to 15% of the infants had oral Candida at the respective age. Colonisation was fairly stable until 6 months of age. There was no conclusive impact of the investigated exposures at entry. Infants with a furry pet at home had a lower frequency of Candida at 3 months, (P < 0.05) whereas all but one colonised infant had older siblings at 12 months (P < 0.01). Lactoferrin in breastmilk was negatively associated with colonisation at 6 months of age. It is concluded that 11 to 15% had oral Candida. Exposure to furry pets and siblings impacted oral Candida.

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“…Dosing and mode of administration of B 221 are still yet to be understood, but according to the authors, a higher dosage might be useful in the management of acute diarrhoea in children, especially in developing countries, avoiding the appearance of prolonged diarrhoea, with its threatening consequences (12) . Svensson et al (97) found that AF can be induced in maternal milk by hydrothermally processed cereal intake. Furthermore, the AF-inducing diet prevented mastitis, a painful infection and inflammation of the breast tissue, probably due to the anti-inflammatory properties of AF.…”

Section: Antisecretory Factor and Endocrine Diarrhoeamentioning

confidence: 99%

Antisecretory factor as a potential health-promoting molecule in man and animals

2010

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Antisecretory factor (AF) is a protein secreted in plasma and other tissue fluids in mammals with proven antisecretory and anti-inflammatory activity; its immunohistological distribution suggests a role in the immune system. The expression level and the distribution of AF protein are altered during an immunological response. Exposure to bacterial toxins induces secretion of AF in plasma, probably reflecting a natural defence mechanism to agents causing diarrhoea, thereby contributing to a favourable clinical outcome and disease termination. An increase of AF levels in plasma by dietary means, such as specially processed cereals (SPC), has been demonstrated in human subjects and animals. Administration of SPC to patients affected by inflammatory bowel disease, gastroenteritis and Ménière's disease relieved symptoms and improved quality of life. A recent study showed the positive effect of SPC diet supplementation on prevention of the effects of exposure to low levels of blast overpressure in rats, reducing the extent of intracranial pressure increase and cognitive function impairment. AF-rich egg yolk powder improved health status in children suffering acute and chronic diarrhoea, reducing the frequency and increasing the consistency of stools. This kind of functional food could be used for prophylaxis in populations exposed to a high risk of morbidity and mortality caused by diarrhoea and as a complementary therapy in patients affected by chronic intestinal inflammatory disease to improve well-being. In pig husbandry AF-inducing diets, owing to their antisecretory activity and anti-inflammatory action, are a suitable option as an alternative to antibiotic growth promoters to counteract post-weaning diarrhoea.

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Induction of anti‐secretory factor in human milk may prevent mastitis

Cited by 23 publications

References 77 publications

Session 1: Feeding and infant development Breast-feeding and immune function

Session 1: Feeding and infant development Breast-feeding and immune function

Prevalence of oral Candida in the first year of life

Antisecretory factor as a potential health-promoting molecule in man and animals

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