Induction of apoptosis by a novel copper-based anticancer compound, Casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cells

Vizcaya-Ruiz, Andrea De; Rivero-Müller, Adolfo; Ruiz-Ramı̀rez, Lena; Kass, George E.N.; Kelland, LR; Orr, Rosanne M.; Dobrota, Miloslav

doi:10.1016/s0887-2333(99)00082-x

Cited by 131 publications

(63 citation statements)

References 23 publications

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“…3) are consistent with the induction of cell death by apoptosis (Verhaegen, 1998). A similar finding was made by Vizcaya-Ruiz et al (2000) who demonstrated the ability of copper based anti-cancer drugs to induce apoptosis in human ovarian carcinoma cells. In that case the induction of apoptosis was monitored by changes in cell morphology, activation of caspases and the degradation of DNA to give a ladder pattern of fragments.…”

Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 79%

Induction of apoptosis in yeast and mammalian cells by exposure to 1,10-phenanthroline metal complexes

Coyle

Kinsella

McCann

et al. 2004

Toxicology in Vitro

102

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1,10-Phenanthroline (phen) and metal-phen complexes display fungicidal and fungiststic activity, disrupt mitochondrial function and induce oxidative stress. We have examined the effect of these drugs on the structure of yeast and mammalian cell organelles and the integrity of cellular DNA. Exposure of Candida albicans to [Mn(phen) 2 (mal)].2H 2 O or [Ag 2 (phen) 3 (mal)].2H 2 O (mal H 2 =malonic acid) resulted in DNA degradation whereas exposure to phen or [Cu(phen) 2 (mal)].2H 2 O did not. All drugs induced extensive changes to the internal structure of yeast cells including retraction of the cytoplasm, nuclear fragmentation and disruption of the mitochondrion. In the case of cultured mammalian cells [Cu(phen) 2 (mal)].2H 2 O induced apoptosis as evidenced by the ladder pattern of DNA fragments following gel electrophoresis and also the blebbing of the cell membrane. The other drugs produced non-specific DNA degradation in mammalian cells. In conclusion, phen and metal-phen complexes have the potential to induce apoptosis in fungal and mammalian cells. Given their distinct mode of action compared to conventional anti-fungal drugs, phen and metal-phen complexes may represent a novel group of anti-fungal agents for use either in combination with existing drugs or in cases where resistance to conventional drugs has emerged. #

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Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 79%

Induction of apoptosis in yeast and mammalian cells by exposure to 1,10-phenanthroline metal complexes

Coyle

Kinsella

McCann

et al. 2004

Toxicology in Vitro

102

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“…Hence, different human and murine cell lines were considered, aiming at establishing murine models of melanoma and/or colon cancer. [20][21][22][23]. For these copper-based drugs, still the mechanism of action is not fully elucidated; most importantly, a number of side effects have been reported, including hematotoxicity [24].…”

Section: Introductionmentioning

confidence: 99%

Nanoformulations of a Potent copper-based Aquaporin Inhibitor With Cytotoxic Effect Against Cancer Cells

Nave

Castro

Rodrigues

et al. 2016

Nanomedicine (Lond.)

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Aim: Development of liposomal formulations of Cuphen, a potent copper-based aquaporin inhibitor with therapeutic potential against melanoma and colon cancer. Materials & methods: Cuphen was incorporated into liposomes using the dehydrationrehydration method. The ability of Cuphen to induce cancer cell death was evaluated by MTS and ViaCount assays. In vivo toxicity studies were performed in BALB/c mice. Results:In vitro studies illustrated the antiproliferative effects of Cuphen in different cancer cell lines, in free form or after incorporation into liposomes. In vivo studies revealed no toxic effects after parenteral administration of Cuphen liposomes. Conclusions: Cuphen liposomes are highly attractive to be further tested in murine models due to the possibility of stabilizing and specifically deliver this metallodrug to tumor sites.

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“…In particular, in the search for new drugs the proposal that complexes based on essential metals may be less toxic than those with non essential ones led to the study of copper based drugs, some of them having an important cytotoxic effect [6][7][8]. Consequently, active copper compounds and their interaction with DNA have attracted great interest [5,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Interaction of Cu-dipeptide complexes with Calf Thymus DNA and antiproliferative activity of [Cu(ala-phe)] in osteosarcoma-derived cells

et al. 2009

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Induction of apoptosis by a novel copper-based anticancer compound, Casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cells

Cited by 131 publications

References 23 publications

Induction of apoptosis in yeast and mammalian cells by exposure to 1,10-phenanthroline metal complexes

Induction of apoptosis in yeast and mammalian cells by exposure to 1,10-phenanthroline metal complexes

Nanoformulations of a Potent copper-based Aquaporin Inhibitor With Cytotoxic Effect Against Cancer Cells

Interaction of Cu-dipeptide complexes with Calf Thymus DNA and antiproliferative activity of [Cu(ala-phe)] in osteosarcoma-derived cells

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