Induction of Apoptosis by Lovastatin through Activation of Caspase‐3 and DNase II in Leukaemia HL‐60 Cells

Wang, Ing-Kae; Lin‐Shiau, Shoei‐Yn; Lin, Jen‐Kun

doi:10.1034/j.1600-0773.2000.pto860207.x

Cited by 17 publications

(19 citation statements)

References 25 publications

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“…(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Cyt, cytochrome c; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; p21 wAF1/CIP1 and p27…”

Section: Antitumor Effects Of Statins In Clinical Studiesmentioning

confidence: 99%

Statins are potential anticancerous agents (Review)

2015

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Abstract. Statins are inhibitors of 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGCR), which is a rate-limiting enzyme in the mevalonate pathway. The pleiotropic effects of statins may be mediated by the inhibition of downstream products such as small GTP-binding proteins, Rho, Ras and Rac whose localization and function are dependent on isoprenylation. Preclinical studies of statins in different cancer cell lines and animal models showed antiproliferative, pro-apoptotic and anti-invasive effects. Notably, statins showed targeted action in cancerous cell lines compared to normal cells. Previous studies have also shown the synergistic effects of statins with chemotherapeutic agents and radiotherapy. This effect of statins was also observed in chemotherapeutic-resistant tumors. Statins were reported to sensitize the cells to radiation by arresting them in the late G1 phase of the cell cycle. Similarly, population-based studies also demonstrated a chemopreventive and survival benefit of statins in various types of cancers. However, this benefit has yet to be proven in clinical trials. The interindividual variation in response to statins may be contributed to many genetic and non-genetic factors, including single-nucleotide polymorphisms in HMGCR gene and the overexpression of heterogeneous nuclear ribonucleoprotein A1, which was reported to reduce HMGCR enzyme activity. However, more studies with large phase III randomized controlled trials in cancer patients should be conducted to establish the effect of statins in cancer prevention and treatment.

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“…(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Cyt, cytochrome c; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; p21 wAF1/CIP1 and p27…”

Section: Antitumor Effects Of Statins In Clinical Studiesmentioning

confidence: 99%

Statins are potential anticancerous agents (Review)

2015

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“…Statins can also activate caspase proteases involved in programmed cell death. Lovastatin induced apoptosis in leukemia and prostatic cancer cells through activation of caspase-7 and caspase-3, respectively (Marcelli et al, 1998;Wang et al, 2000a) and cerivastatin caused cell death in human myeloma tumor cells by activating caspase-3, caspase-8, and caspase-9 (Cafforio et al, 2005). Frick et al (2003) reported multiple statin effects on blood vessel formation by inhibition of angiogenesis through down-regulation of proangiogenic factors, such as VEGF, inhibition of endothelial cell proliferation, and block of adhesion to extracellular matrix.…”

Section: A Effects Of Statins In Cancermentioning

confidence: 99%

Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer

Gazzerro

Proto²,

Gangemi³

et al. 2011

Pharmacol Rev

401

370

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“…Cafforio et al showed that cerivastatin caused cell death in human myeloma tumor cells by activating caspase-3, caspase-8, and caspase-9 [80]. Similarly, lovastatin induces apoptosis in prostatic epithelium and leukemia cells through activation of caspase-3 and caspase-7, respectively [81,82].…”

Section: Induction Of Apoptosismentioning

confidence: 99%

The Role of Statins in Cancer Therapy

Cleeland²,

et al. 2006

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Learning ObjectivesAfter completing this course, the reader will be able to:1. Explain how statins, used in the treatment of hypercholesterolemia, may be applicable to cancer prevention.2. Discuss how statins potentially interfere with biologic processes relevant to cancer etiology. AbstractAdministration of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, to ambulatory patients is associated with a lower incidence of long-term adverse cardiovascular events, including death, myocardial infarction, stroke, atrial fibrillation, and renal dysfunction. However, increasing clinical evidence suggests that statins, independent of their effects on serum cholesterol levels, may also play a potential role in the prevention and treatment of cancer. Specifically, statins have been shown to exert several beneficial antineoplastic properties, including decreased tumor growth, angiogenesis, and metastasis. The feasibility and efficacy of statins for the prevention and treatment of cancer is reviewed. The Oncologist 2006;11:306-315

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Induction of Apoptosis by Lovastatin through Activation of Caspase‐3 and DNase II in Leukaemia HL‐60 Cells

Cited by 17 publications

References 25 publications

Statins are potential anticancerous agents (Review)

Statins are potential anticancerous agents (Review)

Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer

The Role of Statins in Cancer Therapy

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