Induction of apoptosis by tea polyphenols mediated through mitochondrial cell death pathway in mouse skin tumors

Roy, Praveen K.; Nigam, Nidhi; George, Jasmine; Srivastava, Smita; Shukla, Yogeshwer

doi:10.4161/cbt.8.13.8728

Cited by 36 publications

(24 citation statements)

References 30 publications

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“…Under the stimulation of apoptosis involving mitochondria, survivin can form a complex with XIAP, elevate the stability of XIAP and its inhibitory activity against caspases [15,16]. Common cancer treatments currently induce apoptosis by downregulating the expression of survivin [17].…”

Section: Introductionmentioning

confidence: 99%

The role of survivin in oral squamous cell carcinoma

Liang¹,

Guo²,

Liu³

2018

biomedicalresearch

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Tumor samples were collected from 30 patients who were suffered with squamous cell carcinoma of the oral cavity. The patients were treated by radical surgical resection between 2012 and 2015 at the Jinling hospital. There were 24 patients who were positive for survivin (80.0%) and 6 patients who were negative for survivin (20.0%). Compared with normal mucosa, there were significantly up-regulated survivin and caspase 9 in OSCC which were proved by Flow Cytometry (FCM) and western blot, respectively. In conclusion, survivin and Caspase 9 might be prognostic markers for Oral Squamous Cell Carcinoma (OSCC).

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Section: Introductionmentioning

confidence: 99%

The role of survivin in oral squamous cell carcinoma

Liang¹,

Guo²,

Liu³

2018

biomedicalresearch

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“…Several studies have observed a reduction in skin tumor incidence in mice treated with black tea polyphenols potentially via induction of apoptosis [6, 7]. Research in mice, human keratinocytes, and humans also indicates a protective role forepigallocatechin-3-gallate, a catechin in green tea, in skin cancer through several possible pathways, including antioxidant activity, anti-inflammatory effects, and cutaneous photoprotection [8–13].…”

Section: Introductionmentioning

confidence: 99%

Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study

Ferrucci

Cartmel

Molinaro

et al. 2014

European Journal of Cancer Prevention

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Objectives Tea and coffee are hypothesized to play a protective role in skin carcinogenesis via bioactive components, such as caffeine, yet the epidemiologic evidence is mixed. Existing data supports an inverse association with basal cell carcinoma (BCC) more so than for melanoma or squamous cell carcinoma. To understand if tea, coffee, and caffeine are related to early-onset BCC, we evaluated data from 767 non-Hispanic Whites under age 40 in a case-control study in Connecticut. Methods BCC cases (n=377) were identified through Yale's Dermatopathology database. Controls (n=390) were randomly sampled from individuals in the same database with benign skin diagnoses and frequency matched to cases on age, gender, and biopsy site. Subjects completed an in-person interview including assessment of caffeinated coffee and hot tea. We calculated multivariate odds ratios (OR) and 95% confidence intervals (CIs) with unconditional logistic regression for regular consumption and frequency and duration measures. Results Combined regular consumption of caffeinated coffee plus hot tea was inversely associated with early-onset BCC (OR=0.60, 95% CI=0.38–0.96). Those in the highest category of caffeine from these sources had a 43% reduced risk of BCC compared to non-consumers (OR=0.57, 95% CI=0.34–0.95, p-trend=0.037). Conclusions Our findings suggest a modest protective effect for caffeinated coffee plus tea in relation to early-onset BCC that may, in part, be due to caffeine. This study adds to the growing body of literature suggesting potential health benefits from these beverages.

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“…Furthermore, under identical conditions, EGCg suppressed Bcl-xL mRNA expression in non-small-cell lung cancer A549 cells [48]. Bcl-xL, a member of the Bcl-2 family, inhibits apoptosis by blocking the mitochondrial cytochrome c release [49,50]. A decrease in Bcl-xL gene expression may lead to the promotion of cell death.…”

Section: Proposed Mechanism Of the Anti-cancer Effects (Experimental mentioning

confidence: 99%

Green Tea Catechins -Pharmacokinetic Properties and Health Beneficial Effects

ErisaTomishige¹

2015

Pharm Anal Acta

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In this review, we provide information on thepharmacokinetic properties of green tea catechins and their beneficial health effects. The major catechins in green tea are (-)-epicatechin (EC), its hydroxyl derivative (-)-epigallocatechin (EGC), and their gallic acid esters, (-)-epicatechin-3-gallate (ECg) and (-)-epigallocatechin-3-gallate (EGCg). We developed an analytical method for determination of the presence of green tea catechins in human serum using ion-pair HPLC with electrochemical detection to estimate the pharmacokinetic parameters of target catechins. The C max values indicated that catechin absorption was relatively low. One of the gallatedcatechins, EGCg, had a longer half-life than the non-gallatedcatechins. Green tea catechins, in particular, have attracted attention as cancer preventive agents in terms of their low toxicity and being readily available to the general population. Several epidemiological studies revealed that green tea consumption reduces cancer incidence. Numerous in vitro cell culture studies have shown that EGCg, which is defined as a major green tea catechin contributing to green tea's anticancer effects, inhibits cell growth concomitant with induction of apoptosis. We have previously found that the cell death-inhibiting gene, Bcl-xL, was decreased by EGCg. These results support the hypothesis that EGCg regulates cytoplasmic NF-κB and subsequently induction of apoptosis. Green tea consumption may also play a role in preventing other lifestyle diseases, such as cardiovascular diseases and stroke, due to its hypocholesterolemic and hypotensive activities. In conclusion, habitual green tea drinking may promote human health by preventing lifestyle-related diseases.

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Induction of apoptosis by tea polyphenols mediated through mitochondrial cell death pathway in mouse skin tumors

Cited by 36 publications

References 30 publications

The role of survivin in oral squamous cell carcinoma

The role of survivin in oral squamous cell carcinoma

Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study

Green Tea Catechins -Pharmacokinetic Properties and Health Beneficial Effects

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