Induction of Apoptosis by Vinblastine via c-Jun Autoamplification and p53-Independent Down-Regulation of p21^WAF1/CIP1

Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells

“…Our data also show that p27 seems not to be critical for EET-induced proliferation because the inhibition of EET-induced proliferation by the JNK inhibitor is not associated with the upregulation of p27 mRNA and protein expression. And p21, a key transcriptional target of c-Jun, may be directly regulated and repressed by c-Jun, consistent with published data describing a role for c-Jun in negative regulation of the p21 promoter ( 38,39 ).…”

Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells

“…Similarly, the monoterpene indole alkaloid camptothecin (a topoisomerase inhibitor) and its analogues are routine anticancer agents (Lorence and Nessler 2004). These alkaloids are also potent apoptosis inducers in several other malignant cells, such as neuronal cancer cells, human epidermoid carcinoma cells, colon carcinoma cells, retinoblastoma cells, to name a few (Conway et al, 1998;Morris and Geller 1996;Chaturvedula et al, 2003;Kolomeichuk et al, 2008).…”

The automated FADU-assay, a potential high-throughput in vitro method for early screening of DNA breakage

“…Vinblastine provokes the destabilization of microtubules at minus ends and the stabilization at plus ends and may contribute to the altered function of mitotic spindle microtubules (Panda et al, 1996). this leads to mitotic arrest and subsequent cell death by apoptosis (Kolomeichuk et al, 2008). Not all types of anti-tumor drugs induce DNA strand breaks.…”