2000
DOI: 10.1073/pnas.110538897
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Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

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Cited by 224 publications
(200 citation statements)
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“…Small peptides or antisense oligonucleotides that target MDM2 have been shown to activate p53 successfully in p53-positive tumour cells (Böttger et al, 1997;Chen et al, 1999). Similarly, inhibition of the HPV E6 protein can induce p53 in cervical cancer cells (Butz et al, 2000;Hietanes et al, 2000). These approaches may be less effective, however, in those cancers where resistance to p53-mediated tumour suppression results from defects in downstream effectors, such as Bax (Rampino et al, 1997) or Apaf-1 (Soengas et al, 2001).…”
Section: Potential Of P53 In Cancer Therapymentioning
confidence: 99%
“…Small peptides or antisense oligonucleotides that target MDM2 have been shown to activate p53 successfully in p53-positive tumour cells (Böttger et al, 1997;Chen et al, 1999). Similarly, inhibition of the HPV E6 protein can induce p53 in cervical cancer cells (Butz et al, 2000;Hietanes et al, 2000). These approaches may be less effective, however, in those cancers where resistance to p53-mediated tumour suppression results from defects in downstream effectors, such as Bax (Rampino et al, 1997) or Apaf-1 (Soengas et al, 2001).…”
Section: Potential Of P53 In Cancer Therapymentioning
confidence: 99%
“…The viral E6 and E7 oncogenes are both regularly expressed in HPV-positive tumor cells and are necessary to maintain their transformed phenotype (zur Hausen, 2002). E6 exhibits antiapoptotic potential in various experimental settings (Pan and Griep, 1995;Sto¨ppler et al, 1998;Thomas and Banks, 1998;AguilarLemarroy et al, 2002;Filippova et al, 2004;Yuan et al, 2005), and the targeted inhibition of endogenous E6 activity induced apoptosis in HPV-positive cancer cells (Butz et al, 2000(Butz et al, , 2003Hengstermann et al, 2005;Kelley et al, 2005). Thus, the continuous presence of E6 is important for the viability of HPV-positive cancer cells, defining E6 as a promising target for therapeutic intervention.…”
Section: Introductionmentioning
confidence: 99%
“…31). As baits, parts of the ErbB2 intracellular domain (for cytoplasmic domain, amino acids 678-1,254; for KDg, amino acids 678-987; for KDI, amino acids 678-852; and for KDII, amino acids 853-987) were fused to the GAL4-DNA binding domain into the pPC-97 vector.…”
Section: Peptide Aptamer Screeningmentioning
confidence: 99%
“…As baits, parts of the ErbB2 intracellular domain (for cytoplasmic domain, amino acids 678-1,254; for KDg, amino acids 678-987; for KDI, amino acids 678-852; and for KDII, amino acids 853-987) were fused to the GAL4-DNA binding domain into the pPC-97 vector. Screenings were done with a randomized 12-mer and 20-mer peptide aptamer library and selection procedures were done as previously described (31).…”
Section: Peptide Aptamer Screeningmentioning
confidence: 99%
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