Induction of apoptosis of human tumor cells by hybrid liposomes including docosahexaenoic acid

Goto, Kōichi; Tanaka, Yoshihiro; Matsumoto, Yōko; Ueoka, Ryuichi

doi:10.1016/j.bmcl.2008.02.019

Cited by 13 publications

(4 citation statements)

References 16 publications

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“…Among the different fatty acids, liposomal LLA and DHA exhibited particularly high levels of inhibitory activity and inhibited cancer cells via necrosis- and apoptosis-inducing mechanisms, respectively [ 67 ]. It was suggested that liposomal DHA deserved further attention for development on account of inducing cancer cell apoptosis.…”

Section: Application Examplesmentioning

confidence: 99%

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Tan

Yoon

Cho

et al. 2021

IJMS

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There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

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Section: Application Examplesmentioning

confidence: 99%

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Tan

Yoon

Cho

et al. 2021

IJMS

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“…In the course of our study for HLs, the following interesting results have been obtained. (a) Inhibitory effects of HLs including antitumor drugs (Kitamura et al, 1996), sugar surfactants (Matsumoto et al, 2000) or polyunsaturated fatty acids (Goto et al, 2008) have been observed on the growth of tumor cells in vitro and in vivo. (b) High inhibitory effects of HLs on the growth of tumor cells in vitro (Iwamoto et al, 2005;Matsumoto et al, 2005) and in vivo (Shimoda et al, 2009;Ichihara et al, 2012) along with the induction of apoptosis have been observed without using any drugs.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of hybrid liposomes without drugs for rheumatoid arthritis

et al. 2013

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Hybrid liposomes (HLs) can be prepared by simply sonicating a mixture of vesicular and micellar molecules in buffer solutions. This study aims to demonstrate inhibitory effects of HLs on the growth of fibroblast-like synoviocytes along with apoptosis and therapeutic effects of HLs in a mouse model with rheumatoid arthritis (RA). HLs composed of 95 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 5 mol% polyoxyethylene(23)dodecyl ether (C12(EO)23) were prepared by the sonication method. The inhibitory effects of HLs on the growth of human fibroblast-like synoviocytes-RA (HFLS-RA) cells in vitro and their inhibitory mechanism were examined. High inhibitory effects of HLs on the growth of HFLS-RA cells were observed. The induction of apoptosis by HLs was revealed on the basis of flow cytometric analysis. Furthermore, therapeutic effects of HLs in the mouse model with RA were examined in vivo. Our results demonstrate that HLs showed inhibitory effects on the growth of HFLS-RA cells in vitro along with apoptosis and therapeutic effects in mouse models of RA in vivo.

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“…In the course of our study for HLs, the following interesting results have been obtained. (a) Inhibitory effects of HLs including antitumor drugs, 11) sugar surfactants, 12) cationic lipids 13) or polyunsaturated fatty acids 14) have been observed on the growth of tumor cells in vitro and in vivo. (b) High inhibitory effects of HLs on the growth of tumor cells in vitro 15,16) and in vivo 17,18) along with the induction of apoptosis have been obtained without using any drugs.…”

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confidence: 99%

Anti-tumor Effects of Cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis <i>in Vitro</i>

Hino

Ichihara

Matsumoto

et al. 2012

Biological & Pharmaceutical Bulletin

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Induction of apoptosis of human tumor cells by hybrid liposomes including docosahexaenoic acid

Cited by 13 publications

References 16 publications

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Therapeutic effects of hybrid liposomes without drugs for rheumatoid arthritis

Anti-tumor Effects of Cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis <i>in Vitro</i>

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