Induction of Aryl Hydrocarbon Hydroxylase in Human Pulmonary Alveolar Macrophages by Cigarette Smoking

Cantrell, Elroy T.; Warr, Glenn A.; Busbee, David L.; Martin, R. Russell

doi:10.1172/jci107371

Cited by 142 publications

(43 citation statements)

References 24 publications

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“…Although we have studied few subjects, we have failed to demonstrate any difference between smokers and nonsmokers. Since smokers have higher levels of AHH activity than non-smokers in tissues as different as lung (Cantrell, Warr, Busbee & Martin, 1973), liver (Pelkonen, 1976) and placenta (Pelkonen et al, 1972); and since the topical application of cigarette smoke condensates induces epidermal AHH in mouse skin (Norred & Akin, 1976), our results may be due to the relative inaccessibility of epidermal cells to circulating substances derived from cigarettes. Alternatively, our findings could be due to relative tissue specificity of mixed-function oxidases.…”

Section: Discussionmentioning

confidence: 77%

The activity of aryl hydrocarbon hydroxylase in adult human skin.

Chapman¹,

Rawlins²,

Shuster³

1979

Brit J Clinical Pharma

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upon Tyne, Newcastle upon Tyne NE1 7RU 1 Aryl hydrocarbon hydroxylase (AHH), a mixed-function oxidase system, has been identified in microsomal preparations of adult breast skin and foreskin. 2 Separation of dermis from epidermis by stretching, showed that AHH activity in human skin is almost exclusively located within the epidermis.3 Preincubation of whole chopped skin with benzanthracene (5 gM to 100 giM) using a tissue culture system was accompanied by a concentration dependent increase in AHH activity. 4 Although there was no significant difference in AHH activity between the two sites, individuals differed markedly from one another in activity at any one site. Activity was observed to be positively correlated with age.

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Section: Discussionmentioning

confidence: 77%

The activity of aryl hydrocarbon hydroxylase in adult human skin.

Chapman¹,

Rawlins²,

Shuster³

1979

Brit J Clinical Pharma

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“…Cigarette smoke produces approximately a 2-fold increase in oxygen consumption and hydrogen peroxide release in response to phagocytosis (90). Studies have also shown that macrophages from smokers have a significantly higher aryl hydrocarbon hydroxylase (AHH) activity than similar cells from nonsmokers (202,203). This is important, since this enzyme system can metabolize polycyclic aromatic hydrocarbons to more active carcinogens.…”

Section: Alterations In Biochemical Activitiesmentioning

confidence: 99%

Alterations in Macrophage Functions by Environmental Chemicals

Gardner¹

1984

Environmental Health Perspectives

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“…J. ); IgE with a radioimmunoabsorbent method (Pharmacia Laboratories Inc.); and hemolytic complement (C4 and C6 titers) (18,19 Sinice prior studclies lhavxe demonstrated inl normiial subjects that cigarette smiioking can significantly influience thle recovery of respiratory cells (7,(21)(22)(23), resuilts fromii patients with IPF are also segregatedl as to smloking statuis (Table II). The percentage of lavage flutid recovered fromi patients with IPF on no therapy tended to be less thaln from other grouips, particiularly the nonsmoking controls (P = 0.08) ( Table IL) probably secondary to the relative increase in PMNs in these patients.…”

Section: Introductionmentioning

confidence: 99%