Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation

Abstract

BACKGROUND Prostatic innervation may participate in its homeostasis and growth. α‐Adrenergic inhibition alleviates clinical symptoms in benign prostatic hyperplasia. However, the prostatic effect of adrenergic agonists has not been investigated. This study deals with the prostatic effect of subchronic sympathomimetic stimulation. METHODS Male rats received daily subcutaneous injections of the α‐adrenergic agonist phenylephrine, 1, 10, or 20 mg/kg per day, the β‐adrenergic agonist isoproterenol, 1, 2.5 or 5 mg/kg per day, or saline, for 30 days, and the prostates were removed for histopathological examination. RESULTS Phenylephrine induced atypical prostatic hyperplasia, characterized by piling‐up with papillary and cribriform patterns, and budding‐out of epithelial cells. It decreased prostatic secretions and total weight. Similar results were observed in orchidectomized rats receiving exogenous testosterone supplementation. Isoproterenol had no prostatic morphological effect. CONCLUSIONS These results raise the possibility that sympathetic stimuli play a role in normal and aberrant growth and differentiation of prostatic epithelium, and suggests neurostimulants‐treated animals as a model to study the etiology and development of prostatic hyperplasia. Prostate 34:214–221, 1998.© 1998 Wiley‐Liss, Inc.

Immunomodulatory Effect of Red Onion (Allium cepaLinn) Scale Extract on Experimentally Induced Atypical Prostatic Hyperplasia in Wistar Rats

“…Following ligation of the spermatic cord and vessels, testes and epididymis were removed. The remaining stump was pushed back through the inguinal canal into the abdominal cavity, and the scrotal sac was closed by sutures [23]. After castration, the rats were maintained under standard laboratory conditions for 7 days in order to allow a definite involution of the prostatic gland [24].…”

Does the prostatic vascular system contribute to the development of benign prostatic hyperplasia?

“…These lesions were noted to intensify over time. Likewise, Golomb et al [18] showed that phenylephrine, an α-adrenergic agonist that induces hypertension, also induces atypical glandular BPH in treated rats. It remains to be explained why systemic vascular dysfunctions might specifically affect the prostate gland, a question that may be better answered with more research into the vascular system of the human prostate gland.…”

Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment

“…Previous studies showed that phenylephrine treatment induced atypical prostatic hyperplasia and mild fibrosis in the rat ventral prostate (Golomb et al, 1998;Rosenzweig et al, 2004;Rosenzweig-Bublil and Abramovici, 2006). These effects have been related to a tissue repair process occurring subsequent to the inflammatory exudates that takes place during early period of phenylephrine treatment.…”