Induction of autoimmunity after heart transplantation is a major component of the rejection process.

Fedoseyeva, Eugenia V.; Zhang, F.; Orr, Patricia L.; Levin, David B.; Buncke, Harry J.; Bénichou, Gilles

doi:10.1097/00007890-199805131-00072

Cited by 58 publications

(101 citation statements)

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“…24 Thus, just like in the nontransplanted population, autoantibodies cannot be considered neither pathogenic nor pathognomonic. However, they have occasionally been associated with the occurrence of diverse complications, namely renal, 23 cardiac, 25 and liver allograft rejection 26,27 or autoimmune dysfunction. 1,2 As far as de novo AIH is concerned, all of our patients showed seropositivity to autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

“…We studied HLA class I and II polymorphism by standard complement-dependent microcytotoxicity assays and/or by PCR with sequence-specific primers for the following antigens/alleles: A (1,2,3,11,23,24,25,26,29,30,31,32,33,34,66,68,69,80), B (7,8,13,18,27,35,37,38,39,41,42,44,45,47,48,49,50,51,52,53,55,56,57,58,60,61,62,63,64,65,67,70,73), Cw (1,2,3,4,…”

Section: Methodsmentioning

confidence: 99%

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Response to steroids in de novo autoimmune hepatitis after liver transplantation

et al. 2002

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Graft dysfunction associated with autoimmune phenomena has been recently described in liver transplant recipients without previous autoimmune disease. However, the natural history, diagnostic criteria, and definitive therapeutic approach of de novo autoimmune hepatitis (de novo AIH) are poorly understood. We report 12 cases of de novo AIH 27.9 ؎ 24.5 months after liver transplantation: the outcome of 7 patients treated with steroids is compared with a group of 5 nontreated patients. Nontreated patients lost the graft after 5.8 ؎ 2.6 months from de novo AIH onset. All treated patients were alive after 48.4 ؎ 14 (29-65) months from de novo AIH onset, and none of them lost the graft. However, 5 patients relapsed in relation to steroid tapering. All patients presented an atypical antiliver/ kidney cytosolic autoantibody, associated to classical autoantibodies in 10 cases. Histological study showed several degrees of lobular necrosis and inflammatory infiltrate. HLA antigen frequencies and matching were compared with 2 control groups (16 orthotopic liver transplantation [LTX] patients without de novo AIH and 929 healthy blood donors); de novo AIH patients showed a higher prevalence of HLA-DR3 (54.5% vs. 25.9%, P ‫؍‬ .04) than healthy controls, which was not observed in LTX patients without de novo AIH. In conclusion, this new disease should be included in the differential diagnosis of unexplained graft dysfunction. In addition, treatment with steroids results in a dramatically improved outcome. However, maintenance therapy is usually required. (HEPATOLOGY 2002;35:349-356.)

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Response to steroids in de novo autoimmune hepatitis after liver transplantation

et al. 2002

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“…Rather, p21−/− recipients mounted an exaggerated Th1 response relative to WT mice which was associated with accelerated graft rejection (Table I) and exacerbated graft pathology (Figure 1). These differences in the in vitro and in vivo scenarios are likely reflected by the fact that there are clear microenvironmental differences present in vivo following transplantation with differential expression of antigens and compartmentalization of responses that may occur (18)(19)(20)(21)(22)(23)(24)(25). However, the in vivo correlate clearly contains the most relevance as this is most important clinically and reflects the net effect of all of the above variables.…”

Section: Discussionmentioning

confidence: 99%

“…It is generally accepted that immune responses initiated in vitro may not accurately reflect the complexity of responses initiated in vivo where compartmentalization, microenvironmental parameters, and tissue specific expression of antigens may impact outcome (18)(19)(20)(21)(22)(23)(24)(25). Therefore we assessed the ability of WT and p21−/− mice to mount proliferative and cytokine responses following cardiac transplantation.…”

Section: Impact Of P21 On In Vivo T Cell Responses Following Transplamentioning

confidence: 99%

Regulation of alloimmune Th1 responses by the cyclin-dependent kinase inhibitor p21 following transplantation

Welling

Csencsits

et al. 2008

Surgery

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Background-The cyclin-dependent kinase (cdk) inhibitor p21 inhibits cellular proliferation of many cell types, including T cells. However, autoimmune models have yielded conflicting results regarding the role of cdk inhibitors and T cell function. The role of p21 in T cell function following transplantation has not been directly investigated. We hypothesized that p21 plays an important role in alloantigen-driven responses in vitro in mixed lymphocyte cultures (MLC) and in vivo using the heterotopic murine cardiac allograft model.

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“…This is the activation of autoreactive lymphocytes by antigen presenting cells in a proinflammatory environment (Fujinami, et al, 2006). This kind of autoreactive T cells activation has been described in Chagas'disease (Fedoseyeva, et al, 1999).…”

Section: Cellular Adaptative Immunitymentioning

confidence: 95%

Pathogenesis and Pathology of Chagas' Chronic Myocarditis

González¹,

Guerri-Guttenberg²,

Grana³

et al. 2011

Myocarditis

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Induction of autoimmunity after heart transplantation is a major component of the rejection process.

Cited by 58 publications

References 0 publications

Response to steroids in de novo autoimmune hepatitis after liver transplantation

Response to steroids in de novo autoimmune hepatitis after liver transplantation

Regulation of alloimmune Th1 responses by the cyclin-dependent kinase inhibitor p21 following transplantation

Pathogenesis and Pathology of Chagas' Chronic Myocarditis

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