Induction of Bent Cartilaginous Skeletons and Undulating Notochord in Flounder Embryos by Disulfiram and α, α'-Dipyridyl

Alterações histológicas dos rins e expressão das metalotioneínas e das proteínas de choque térmico em ratos Wistar após exposição ao fungicida tirame

“…Contracoloração com hematoxilina de Mayer. (Suzuki et al, 2000(Suzuki et al, , 2001, atividade anti-angiogênica (Marikovsky, 2002) e formação de quelatos com o cobre e o zinco, elementos essenciais como cofatores para várias enzimas (Dalvi, 1988). Funcionalmente, as MTs atuam principalmente como reguladoras da homeostase de metais nos tecidos e também como um potente antioxidante que protege as células ou os tecidos dos danos oxidativos.…”

Effect of dithiocarbamate thiram on Wistar rat growth plate and articular cartilage

“…Thiram is available as dust, wettable powder, water suspension formulations, and in mixtures with other fungicides (Dalvi et al, 1988;see Extonet, 2011). Toxic and some tumorigenic effects have been observed in different animal species exposed to thiram (Dalvi, 1988;Maita et al, 1991;Extonet, 2011), numerous tests indicate that it is genotoxic (Crebelli et al, 1992;Hemavathi and Rahiman, 1996) and effects on cartilaginous tissues in vitro (Rath et al, 1995) and in vivo, in different animal species exposed to dithiocarbamtes, including thiram, were reported (Enomoto et al, 1989;Suzuki et al, 2000Suzuki et al, , 2001Rath et al, 2004;Simsa et al, 2007). The purpose of this study was to evaluate the effects of the dithiocarbamate thiram on the growth plate and articular cartilage of mammals, using Wistar rats as experimental model.…”

“…Mechanisms of biological effects of dithiocarbamates include the chelation of certain important elements as copper and zinc, which are essential as cofactors for many enzymes (Dalvi, 1998), disruption in proteoglicans synthesis, collagen maturation, secondary effects in prolilhydroxilase activity (Suzuki et al, 2000;2001), and anti-angiogenic activity (Marikovsky, 2002).…”