Induction of Bone in Composites of Osteogenin and Porous Hydroxyapatite in Baboons

Ripamonti, Ugo; Ma, Shu-Shan; Reddi, A. Hari

doi:10.1097/00006534-199204000-00025

Cited by 50 publications

(31 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This correlates with a number of studies in which HA granules and other bone substitutes have been combined with various osteoinductive agents, such as BMP-3, PDGF, TGF-b or DBM at skeletal or extraskeletal sites , Ripamonti et al 1992, Ono et al 1996.…”

Section: Discussionsupporting

confidence: 77%

Osteogenic protein 1 device increases bone formation and bone graft resorption around cementless implants

Jensen¹,

Overgaard²,

Lind³

et al. 2002

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 77%

Osteogenic protein 1 device increases bone formation and bone graft resorption around cementless implants

Jensen¹,

Overgaard²,

Lind³

et al. 2002

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

show abstract

“…With a hydroxyapatite carrier, the BMP also seemed active. However, even the carrier alone caused bone formation, and the role of the BMP was uncertain (Ripamonti et al 1992b). It appears that extraskeletal bone induction in baboons is rather easily achieved.…”

Section: Discussionmentioning

confidence: 99%

BMP-2 for intramuscular bone induction:Effect in squirrel monkeys is dependent on implantation site

Aspenberg¹,

Turek²

1996

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

“…BMPs have also been delivered from porous hydroxyapatite (HAP) [28,29], poly(lactide) (PLLA) [7,30], poly(lactic-co-glycolic acid) (PLGA) [31,32] for bone regeneration. However, these carriers have achieved no better success than collagen matrix and none of them has gained acceptance for human clinical investigation.…”

Section: Introductionmentioning

confidence: 99%

The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres

et al. 2007

View full text Add to dashboard Cite

It is advantageous to incorporate controlled growth factor delivery into tissue engineering strategies. The objective of this study was to develop a three-dimensional (3D) porous tissue engineering scaffold with the capability of controlled releasing recombinant human bone morphogenetic protein-7 (rhBMP-7) for enhancement of bone regeneration. RhBMP-7 was first encapsulated into poly(lactic-co-glycolic acid) (PLGA) nanospheres (NS) with an average diameter of 300 nm. Poly (L-lactic acid) (PLLA) scaffolds with interconnected macroporous and nano-fibrous architectures were prepared using a combined sugar sphere template leaching and phase separation technique. A post-seeding technique was then utilized to immobilize rhBMP-7 containing PLGA nanospheres onto prefabricated nano-fibrous PLLA scaffolds with well maintained 3D structures. In vitro release kinetics indicated that nanosphere immobilized scaffold (NS-scaffold) could release rhBMP-7 in a temporally controlled manner, depending on the chemical and degradation properties of the nanospheres which were immobilized onto the scaffold. In vivo, rhBMP-7 delivered from NSscaffolds induced significant ectopic bone formation throughout the scaffold while passive adsorption of rhBMP-7 into the scaffold resulted in failure of bone induction due to either the loss of rhBMP-7 biological function or insufficient duration within the scaffold. We conclude that the interconnected macroporous architecture and the sustained, prolonged delivery of bioactive rhBMP-7 from NS immobilized nano-fibrous scaffolds actively induced new bone formation throughout the scaffold. The approach offers a new delivery method of BMPs and a novel scaffold design for bone regeneration.

show abstract

Induction of Bone in Composites of Osteogenin and Porous Hydroxyapatite in Baboons

Cited by 50 publications

References 0 publications

Osteogenic protein 1 device increases bone formation and bone graft resorption around cementless implants

Osteogenic protein 1 device increases bone formation and bone graft resorption around cementless implants

BMP-2 for intramuscular bone induction:Effect in squirrel monkeys is dependent on implantation site

The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres

Contact Info

Product

Resources

About