Induction of c-Fos expression by electrical stimulation of the nucleus basalis magnocellularis

Boix-Trelis, Núria; Vale-Martínez, Anna; Guillazo-Blanch, Gemma; Martí-Nicolovius, Margarita

doi:10.1016/j.neulet.2008.10.105

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…The PC is the largest area of the mammalian olfactory cortex, receives direct projections from the olfactory bulb and contains the most susceptible neural circuits of all forebrain regions for electrical (or chemical) stimulation [49, 50]. Thus, immunohistochemical studies have shown that during electrical stimulation of limbic brain regions, the PC exhibits the most consistent increase in glucose utilization [49], similar to our results.…”

Section: Discussionsupporting

confidence: 87%

Response to Deep Brain Stimulation in Three Brain Targets with Implications in Mental Disorders: A PET Study in Rats

et al. 2016

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ObjectiveTo investigate metabolic changes in brain networks by deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC), nucleus accumbens (NAcc) and dorsomedial thalamus (DM) using positron emission tomography (PET) in naïve rats.Methods43 male Wistar rats underwent stereotactic surgery and concentric bipolar platinum-iridium electrodes were bilaterally implanted into one of the three brain sites. [18F]-fluoro-2-deoxy-glucose-PET (18FDG-PET) and computed tomography (CT) scans were performed at the 7th (without DBS) and 9th day (with DBS) after surgery. Stimulation period matched tracer uptake period. Images were acquired with a small-animal PET-CT scanner. Differences in glucose uptake between groups were assessed with Statistical Parametric Mapping.ResultsDBS induced site-specific metabolic changes, although a common increased metabolic activity in the piriform cortex was found for the three brain targets. mPFC-DBS increased metabolic activity in the striatum, temporal and amygdala, and reduced it in the cerebellum, brainstem (BS) and periaqueductal gray matter (PAG). NAcc-DBS increased metabolic activity in the subiculum and olfactory bulb, and decreased it in the BS, PAG, septum and hypothalamus. DM-DBS increased metabolic activity in the striatum, NAcc and thalamus and decreased it in the temporal and cingulate cortex.ConclusionsDBS induced significant changes in 18FDG uptake in brain regions associated with the basal ganglia-thalamo-cortical circuitry. Stimulation of mPFC, NAcc and DM induced different patterns of 18FDG uptake despite interacting with the same circuitries. This may have important implications to DBS research suggesting individualized target selection according to specific neural modulatory requirements.

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Section: Discussionsupporting

confidence: 87%

Response to Deep Brain Stimulation in Three Brain Targets with Implications in Mental Disorders: A PET Study in Rats

et al. 2016

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“…Therefore, given the large system of horizontal connections between sensory areas (Stehberg et al, 2014), EES may induce extensive functional changes in the brain cortex. In addition c-Fos immunocytochemistry has been used as an activity marker which was overexpressed after electrical stimulation of the brain (Boix-Trelis et al, 2009). Thus, the third goal of this paper was to analyze cortical effects of repeated anodal EES by Nissl staining and c-Fos quantitative immunocytochemistry.…”

Section: Introductionmentioning

confidence: 99%

Reversible Functional Changes Evoked by Anodal Epidural Direct Current Electrical Stimulation of the Rat Auditory Cortex

et al. 2019

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Rat auditory cortex was subjected to 0.1 mA anodal direct current in seven 10-min sessions on alternate days. Based on the well-known auditory cortex control of olivocochlear regulation through corticofugal projections, auditory brainstem responses (ABRs) were recorded as an indirect test of the effectiveness and reversibility of the multisession protocol of epidural stimulation. Increases of 20–30 dB ABR auditory thresholds shown after epidural stimulation reverted back to control levels 10 min after a single session. However, increases in thresholds revert 4 days after multisession stimulation. Less changes in wave amplitudes and threshold shifts were shown in ABR recorded contralaterally to the electrically stimulated side of the brain. To assess tissue effects of epidural electric stimulation on the brain cortex, well characterized functional anatomical markers of glial cells (GFAP/astrocytes and Iba1/microglial cells) and neurons (c-Fos) were analyzed in alternate serial sections by quantitative immunocytochemistry. Restricted astroglial and microglial reactivity was observed within the cytoarchitectural limits of the auditory cortex. However, interstitial GFAP overstaining was also observed in the ventricular surface and around blood vessels, thus supporting a potential global electrolytic stimulation of the brain. These results correlate with extensive changes in the distribution of c-Fos immunoreactive neurons among layers along sensory cortices after multisession stimulation. Quantitative immunocytochemical analysis supported this idea by showing a significant increase in the number of positive neurons in supragranular layers and a decrease in layer 6 with no quantitative changes detected in layer 5. Our data indicate that epidural stimulation of the auditory cortex induces a reversible decrease in hearing sensitivity due to local, restricted epidural stimulation. A global plastic response of the sensory cortices, also reported here, may be related to electrolytic effects of electric currents.

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“…These include increased nerve growth factor (NGF) secretion and enhanced neurogenesis (Hotta et al, 2009 ; Jeong Da et al, 2014 ) (Figure 2 ). In terms of short term effects of NBM DBS, animal studies have indicated that NBM DBS is linked to brain plasticity and cortical map reorganization(Kilgard and Merzenich, 1998 ), and associated with enhanced learning and induction of immediate-early gene c-Fos (Boix-Trelis et al, 2006 , 2009 ).…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

Disease-modifying therapeutic directions for Lewy-Body dementias

2015

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Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB.

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Induction of c-Fos expression by electrical stimulation of the nucleus basalis magnocellularis

Cited by 9 publications

References 39 publications

Response to Deep Brain Stimulation in Three Brain Targets with Implications in Mental Disorders: A PET Study in Rats

Response to Deep Brain Stimulation in Three Brain Targets with Implications in Mental Disorders: A PET Study in Rats

Reversible Functional Changes Evoked by Anodal Epidural Direct Current Electrical Stimulation of the Rat Auditory Cortex

Disease-modifying therapeutic directions for Lewy-Body dementias

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