Induction of cardiotoxicity in zebrafish embryos by 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene through the JAK-STAT and NOTCH signaling pathways

Frontier of toxicology studies in zebrafish model

“…mechanisms, among which the observed indicators of cardiovascular toxicity were pericardial edema Maciag et al, 2022;Nie et al, 2022;Xu, Huang, et al, 2022;Yan et al, 2022;Zhu, Wang, et al, 2022;Zong et al, 2022), heart rate changes (Du et al, 2022;Fan, Yang, et al, 2022;Maciag et al, 2022;Nie et al, 2022;Xu, Huang, et al, 2022;Yan et al, 2022;Zong et al, 2022), and sinus venous-bulb arterial (SV-BA) distance changes (Chen, Qiu, et al, 2022;Du et al, 2022;Nie et al, 2022;Xu, Huang, et al, 2022;Zhu, Wang, et al, 2022), increased pericardial areas (Chen, Qiu, et al, 2022;, detailed in Table S3, Figure 3, and Figure 4. F I G U R E 3 Mechanism of cardiovascular toxic oxidative stress in zebrafish.…”

“…The zebrafish cardiovascular system begins to perform function at 24 hpf and completes heart development at 72 hpf. After the 2022 literature study on zebrafish cardiovascular toxicity, there were 14 research articles on zebrafish cardiovascular toxicity and mechanisms, among which the observed indicators of cardiovascular toxicity were pericardial edema (Huang, Wang, et al, 2022; Maciag et al, 2022; Nie et al, 2022; Xu, Huang, et al, 2022; Yan et al, 2022; Zhang, Wang, et al, 2022; Zhu, Wang, et al, 2022; Zong et al, 2022), heart rate changes (Du et al, 2022; Fan, Yang, et al, 2022; Lu, Wang, Zhang, et al, 2022; Maciag et al, 2022; Nie et al, 2022; Xu, Huang, et al, 2022; Yan et al, 2022; Zong et al, 2022), and sinus venous‐bulb arterial (SV‐BA) distance changes (Chen, Qiu, et al, 2022; Du et al, 2022; Huang, Wang, et al, 2022; Lu, Wang, Zhang, et al, 2022, Lu, Wang, Xu, et al, 2022; Nie et al, 2022; Xu, Huang, et al, 2022; Zhu, Wang, et al, 2022), increased pericardial areas (Chen, Qiu, et al, 2022; Huang, Wang, et al, 2022; Lu, Wang, Zhang, et al, 2022, Lu, Wang, Xu, et al, 2022), detailed in Table S3, Figure 3, and Figure 4. The chemical structures of the samples under related study are shown in Figure S3.…”