Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3

Yim, Sunghan; Dhawan, Puneet; Ragunath, Chandran; Christakos, Sylvia; Diamond, Gill

doi:10.1016/j.jcf.2007.03.003

Cited by 310 publications

(259 citation statements)

References 40 publications

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“…56 LL-37 may also have anti-inflammatory properties, which counteract the effects of the gram-negative endotoxin lipopolysaccharide. 57 Recent research has focused on the relationship between vitamin D and the regulation of the LL-37 gene in sinonasal epithelial cells 58,59 and the implications of this in innate immunity, 60 CRS, and allergic rhinitis. [61][62][63][64] Reactive oxygen and nitrogen species generated by the sinonasal epithelium are also thought to play an essential role in upper airway innate immunity.…”

Section: Antimicrobial Peptides and Radicalsmentioning

confidence: 99%

New Insights into Upper Airway Innate Immunity

Hariri

Cohen

2016

Am J Rhinol�Allergy

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Section: Antimicrobial Peptides and Radicalsmentioning

confidence: 99%

New Insights into Upper Airway Innate Immunity

Hariri

Cohen

2016

Am J Rhinol�Allergy

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“…1, the antimicrobial peptide cathelicidin LL37 is a direct target for liganded VDR. The transcriptional regulation of LL37 by 1,25(OH) 2 D has been described in a variety of cell types including macrophages (Liu et al 2006(Liu et al , 2007b, myeloid cells (Gombart et al 2005), keratinocytes (Schauber et al 2007), decidual cells (Evans et al 2006), and lung epithelial cells (Yim et al 2007). Although this appears to be a fundamental facet of innate immunity in humans, similar responses are not apparent in lower orders of mammals such as mice (Gombart et al 2005).…”

Section: Co-chaperones and The Intracellular Trafficking Of Vitamin Dmentioning

confidence: 99%

Back to the future: a new look at ‘old’ vitamin D

Chun¹,

Adams²,

Hewison³

2008

Journal of Endocrinology

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Our perception of the vitamin D system continues to evolve. Recent studies have re-evaluated the parameters for adequate vitamin D status in humans, revealing a high prevalence of insufficiency in many populations throughout the world. Other reports have highlighted the potential consequences of vitamin D insufficiency beyond established effects on bone homeostasis. Most notably, there is now strong evidence of a role for vitamin D in modulating innate and adaptive immunities, with insufficiency being linked to infectious disease and other immune disorders. To date, signaling pathways for these new responses to vitamin D have been based on established endocrine models for active 1,25-dihydroxyvitamin D, despite present evidence for more localized, intracrine modes of action. In the following review, we provide a fresh perspective on vitamin D signaling in nonclassical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid.

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“…The incidence is more in asians, may be due to poor absorption of ultra violet rays due to melanin and/or dietary or genetic factors. Ultraviolet (UV) B radiation with wave length of 290-320 nano meters converts cutaneous dehydrocholesterol to previtamin D 3 . The bright scorchy sunlight may itself destroy the vitamin D produced in the skin.…”

Section: Discussionmentioning

confidence: 99%

“…Most of these pathogens are sensitive to anti-microbials, cathelicidin and defensin released by the body defense mechanism under the influence of vitamin D [1][2][3][4]. The Upper respiratory tract infection (URTI) results in acute neutrophilic infiltration in respiratory epithelium and production of mucous.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency in E.N.T. Patients

Taneja¹,

Taneja

2012

Indian J Otolaryngol Head Neck Surg

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A prospective study to observe the prevalence of deficiency of vitamin D in out patients of otolaryngology clinic at Indian Institute of ear diseases, Muzaffarnagar. The patients attending outpatient of otolaryngology clinic with various complaints and not responding to conventional treatment were advised for assessment of vitamin D [25 (OH)D] level in blood. The age, sex, occupation, colour of skin, chief complaints, obesity, provisional diagnosis, and incidence of sun exposure was noted in all cases. A total of 86 patients were examined, maximum patients were in the age group of 7-15 years. The chief complaints in majority of the patients were sore throat with recurrent upper respiratory tract infection. Only in three patient's vitamin D level was found to be with in normal limits. In rest 83 (96.51 %) it was either deficient 57 (66.28 %) or insufficient 21 (24.42 %). The incidence of vitamin D deficiency is extremely common in Ear Nose Throat disease (E.N.T.) patients. The results of vitamin supplementation were promising in cases of benign paroxysmal positional vertigo with cervical spondylosis and URTI with asthma, empirical supplementation of vitamin D in all E.N.T. patients not responding to conventional treatment is worth trying. At place of sun screen, use of pomegranates and blueberries may be encouraged to prevent sunburn and eliminate Vitamin D deficiency.

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Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3

Abstract: Elucidation of the effect of 1,25(OH)(2)D(3) on cathelicidin expression in NHBE cells and CF bronchial epithelial cells will aid in the development of novel therapeutic agents for treatment of airway infections in CF.

Cited by 310 publications

References 40 publications

New Insights into Upper Airway Innate Immunity

New Insights into Upper Airway Innate Immunity

Back to the future: a new look at ‘old’ vitamin D

Vitamin D Deficiency in E.N.T. Patients

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