Induction of Cell Death in Renal Cell Carcinoma With Combination of D-Fraction and Vitamin C

Alexander, Bobby; Fishman, Andrew I.; Eshghi, Majid; Choudhury, Muhammad; Konno, Sensuke

doi:10.1177/1534735412473643

Cited by 14 publications

(13 citation statements)

References 24 publications

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“…On the contrary, vitamin C assisted low-dose MTX to exhibit a strong cytotoxic effect in Hep3B cells. Similarly, recent studies also indicated that vitamin C can enhance anticancer agents to exert a strong cytotoxic effect on cancer cells, although the mechanisms remain unknown (48,70–72). Thus, MTX-induced increases in H 2 O 2 levels may be one of the factors resulting in cytotoxicity noted in MTX-treated Hep3B cells.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin C enhances anticancer activity in methotrexate-treated Hep3B hepatocellular carcinoma cells

et al. 2014

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Methotrexate (MTX) has been widely used for rheumatoid arthritis therapy for a long time. MTX is also used as an anticancer drug for various tumors. However, many studies have shown that high-dose MTX treatment for cancer therapy may cause liver and renal damage. Alhough the mechanisms involved in MTX-induced liver and renal damage require further research, many studies have indicated that MTX-induced cytotoxicity is associated with increases in oxidative stress and caspase activation. In order to reduce MTX-induced side-effects and increase anticancer efficiency, currently, combination treatments of low-dose MTX and other anticancer drugs are considered and applied for various tumor treatments. The present study showed that MTX induces increases in H2O2 levels and caspase-9/-3 activation leading to cell death in hepatocellular carcinoma Hep3B cells. Importantly, this study is the first to demonstrate that vitamin C can efficiently aid low-dose MTX in inducing cell death in Hep3B cells. Therefore, the present study provides a possible powerful therapeutic method for tumors using a combined treatment of vitamin C and low-dose MTX.

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Section: Discussionmentioning

confidence: 99%

“…Alternatively, there have been many reports on the antioxidant activities of vitamin C (43–47). Moreover, some studies have demonstrated that vitamin C can exert anticancer activities in various cancer cells (48–52). The present study demonstrated that vitamin C can diminish MTX-induced increases in H 2 O 2 levels.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C enhances anticancer activity in methotrexate-treated Hep3B hepatocellular carcinoma cells

et al. 2014

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“…Chen et al (23) showed as well that VHL-deficient 769-P renal cancer cells are sensitive to megadose Vc, but the authors did not assess whether VHL re-expression reduces this effect. Moreover, Alexander et al (65) demonstrated that ACHN renal cancer cells are highly sensitive to a combination of the D-fraction of the Maitake mushroom and Vc , although it should be noted that this cancer cell line is VHL-competent. VHL-defective renal cancers compose the vast majority of renal cancers in the adult (42), and a proportion of these cancers is familial in the context of the VHL syndrome (42).…”

Section: Discussionmentioning

confidence: 99%

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

Tian

Wang

et al. 2014

Journal of Biological Chemistry

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Background:There is renewed interest in the possibility of using Vc as an anticancer agent. Results: Activation of HIF triggers a Warburg effect that renders cancer cells more sensitive to Vc-induced toxicity. Conclusion: These results provide a link between the metabolic state and the susceptibility to Vc. Significance: Our work helps to understand the preferential toxicity of Vc toward cancer cells.

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“…As mentioned previously, the antitumor properties of the Maitake DFraction are attributed to its immunomodulatory effect. Reports have also indicated that Maitake directly induce apoptosis in tumour cells such as prostate [33], stomach [34], kidney [35] and breast [36] cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

Braico¹,

Roldan-Deamicis²,

Brie³

et al. 2017

Biol Med (Aligarh)

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Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process.

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Induction of Cell Death in Renal Cell Carcinoma With Combination of D-Fraction and Vitamin C

Cited by 14 publications

References 24 publications

Vitamin C enhances anticancer activity in methotrexate-treated Hep3B hepatocellular carcinoma cells

Vitamin C enhances anticancer activity in methotrexate-treated Hep3B hepatocellular carcinoma cells

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

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