Induction of Chromosomal Aberrations and Growth-Transformation of Lymphoblastoid Cell Lines by Inhibition of Reactive Oxygen Species-Induced Apoptosis with Interleukin-6

Miwa, Hideaki; Kanno, Hiroyuki; Munakata, Satoru; Akano, Yumiko; Aozasa, Katsuyuki

doi:10.1038/labinvest.3780076

Cited by 7 publications

(6 citation statements)

References 43 publications

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“…It is well known that IL-6 is an endogenous cytokine released by monocytes, T cells, and vascular endothelial cells and is a major inducer of the inflammation [41]. IL-6 can promote the differentiation of lymphocytes and amplify the inflammatory response leading to tissue damage [42]. In this study, there was a correlation between elevated levels of IL-6 and delirium, both of which were present at reduced levels in the FTS treatment group.…”

Section: Discussionsupporting

confidence: 52%

Fast-track surgery decreases the incidence of postoperative delirium and other complications in elderly patients with colorectal carcinoma

Jia

Jin

Guo³

et al. 2013

Langenbecks Arch Surg

109

101

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ObjectiveThis study aims to investigate the role of fast-track surgery in preventing the development of postoperative delirium and other complications in elderly patients with colorectal carcinoma.MethodsA total of 240 elderly patients with colorectal carcinoma (aged ≥70 years) undergoing open colorectal surgery was randomly assigned into two groups, in which the patients were managed perioperatively either with traditional or fast-track approaches. The length of hospital stay (LOS) and time to pass flatus were compared. The incidence of postoperative delirium and other complications were evaluated. Serum interleukin-6 (IL-6) levels were determined before and after surgery.ResultsThe LOS was significantly shorter in the fast-track surgery (FTS) group than that in the traditional group. The recovery of bowel movement (as indicated by the time to pass flatus) was faster in the FTS group. The postoperative complications including pulmonary infection, urinary infection and heart failure were significantly less frequent in the FTS group. Notably, the incidence of postoperative delirium was significantly lower in patients with the fast track therapy (4/117, 3.4 %) than with the traditional therapy (15/116, 12.9 %; p = 0.008). The serum IL-6 levels on postoperative days 1, 2, and 3 in patients with the fast-track therapy were significantly lower than those with the traditional therapy (p < 0.001).ConclusionsCompared to traditional perioperative management, fast-track surgery decreases the LOS, facilitates the recovery of bowel movement, and reduces occurrence of postoperative delirium and other complications in elderly patients with colorectal carcinoma. The lower incidence of delirium is at least partly attributable to the reduced systemic inflammatory response mediated by IL-6.

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Section: Discussionsupporting

confidence: 52%

Fast-track surgery decreases the incidence of postoperative delirium and other complications in elderly patients with colorectal carcinoma

Jia

Jin

Guo³

et al. 2013

Langenbecks Arch Surg

109

101

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“…Given the central role of IL‐1 and IL‐6 in the above studies, one may postulate that chronic inflammation may play an important role in the progression of myeloma in certain individuals. Inflammation can contribute to the development of neoplasia through the generation of reactive oxygen and nitrogen species resulting in DNA mutations and the production of inflammatory cytokines that can support and perpetuate these genetically altered cells . Indeed the fact that myeloma is one of the more frequently found cancers in workers that were exposed to the World Trade Center dust supports this idea .…”

Section: Discussionmentioning

confidence: 99%

Reduction in C‐reactive protein indicates successful targeting of the IL‐1/IL‐6 axis resulting in improved survival in early stage multiple myeloma

et al. 2016

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We report the long-term follow-up results of a phase II trial of IL-1 receptor antagonist and low-dose dexamethasone for early stage multiple myeloma (MM). Patients were eligible if they had smoldering multiple myeloma (SMM) or indolent multiple myeloma (IMM) without the need for immediate therapy. Forty seven patients were enrolled and subsequently treated with IL-1Ra; in 25/47 low-dose dexamethasone (20 mg weekly) was added. The primary endpoint was progression-free survival (PFS). In the clinical trial, three patients achieved a minor response (MR) to IL-1Ra alone; five patients a partial response (PR) and four patients an MR after addition of dexamethasone. Seven patients showed a decrease in the plasma cell labeling index (PCLI) which paralleled a decrease in the high sensitivity C-reactive protein (hs-CRP). The median PFS for the 47 patients was 1116 days (37.2 months). The median PFS for patients without (n 5 22) and with (n 5 25) a decrease in their baseline hs-CRP was 326 days (11 months) vs. 3139 days (104 months) respectively (P <0.0001). The median overall survival (OS) for the 47 patients was 3482 days (9.5 years). The median OS for patients without and with a decrease in their baseline hs-CRP was 2885 days (7.9 years) vs. median not reached, respectively (P 5 0.001). In SMM/IMM patients at risk for progression to active myeloma, reduction in the hs-CRP indicates successful targeting of the IL-1/IL-6 axis resulting in improved PFS and OS. (Clinical Trials.gov Identifier: NCT00635154) Am. J. Hematol. 91:571-574,

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“…These findings suggest that the PAL is composed of B lymphocytes at the differentiation stage of the postgerminal center but the antigen-dependent maturation is not usually involved in the development of tumor which is distinct from the majority of B cell lymphomas including diffuse large B cell lymphoma. Genetic abnormalities such as p53 gene mutation [6]and chromosomal aberration [3, 5]occurring in long-standing inflammatory lesions, i.e. chronic pyothorax, might be the main driving force in the PAL development.…”

Section: Discussionmentioning

confidence: 99%

“…IL-6 showed a growth promotional effect on the lymphoma cells [3]and IL-10, an immunosuppressive cytokine, might protect the proliferating cells from immune surveillance by host cytotoxic T cells [4]. Reactive oxygen species released by polymorphonuclear leukocytes and macrophages could cause DNA damage in B cells, and thus might contribute to lymphomagenesis [5]. In addition, an unusually high frequency of p53 gene mutations was detected in approximately 70% of PAL cases [6].…”

Section: Introductionmentioning

confidence: 99%

DNA Sequences of the Immunoglobulin Heavy Chain Variable Region Gene in Pyothorax-Associated Lymphoma

et al. 2002

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B cell lymphoma develops in the pleural cavity of patients affected by long-standing pyothorax resulting from lung tuberculosis, thus termed pyothorax-associated lymphoma (PAL). PAL usually shows a diffuse large cell morphology, and constantly contains Epstein-Barr virus (EBV) genome. To investigate whether PAL cells proliferate in response to specific antigenic stimuli and its stage in B cell differentiation, immunoglobulin heavy chain gene in 7 cases and 2 cell lines from PAL, all confirmed by histological studies to be EBV-positive diffuse large B cell lymphoma, were examined by using polymerase chain reaction (PCR) method. Clonal rearrangement of the gene was detected in 4 cases of PAL tissues and one cell line. As for the usage of the V region gene (V_H), the V_H3 family gene was used in 3 of these 5 cases with different homologous germlines, suggesting that the origin of PAL cells from a repertoire of B lymphocytes responsive to specific antigenic epitope was unlikely. Compared to the homologous germline, the mutation frequency of PAL was 9% on average. Only one case might have more replacement mutations in the complementarity-determining regions than expected by chance, thus antigen-selected maturation might not take place in PAL. Intraclonal sequence heterogeneity in the V_H gene was found in another case. From these findings, it is concluded that PAL is composed of B lymphocytes at the differentiation stage of the postgerminal center. Antigen-selected maturation might not take place in PAL, which is distinct from the majority of B cell lymphomas.

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Induction of Chromosomal Aberrations and Growth-Transformation of Lymphoblastoid Cell Lines by Inhibition of Reactive Oxygen Species-Induced Apoptosis with Interleukin-6

Cited by 7 publications

References 43 publications

Fast-track surgery decreases the incidence of postoperative delirium and other complications in elderly patients with colorectal carcinoma

Fast-track surgery decreases the incidence of postoperative delirium and other complications in elderly patients with colorectal carcinoma

Reduction in C‐reactive protein indicates successful targeting of the IL‐1/IL‐6 axis resulting in improved survival in early stage multiple myeloma

DNA Sequences of the Immunoglobulin Heavy Chain Variable Region Gene in Pyothorax-Associated Lymphoma

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