Induction of Combination Therapy for the Management of Hepatitis C: An Observational Study

Khan, Sultan Zeb; Talha, Muhammad Umar; Iftikhar, Bushra; Noor, Amina; Laique, Talha; Latif, Aamna; Malik, Jahanzeb

doi:10.7759/cureus.10259

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…The highest prevalence of positive cases of Hepatitis B and Hepatitis C in our study, were found in age group 30-40 years (table 2) As [4] also had similar results where both hepatitis B and C were seen be highly prevalent in the age group between 30-40 years, while lowest number of positive cases were found in age group 20-30 which may indicate that incidence increased as age increased in study patients.…”

Section: Discussionsupporting

confidence: 85%

“…Study show that The prevalence is continuing to rise especially in rural and local area show (table 4) and the percentage of infected individuals is significantly higher in female than male(table 1) while other studies in Pakistan [4] showed that the total prevalence of Hepatitis C in males was very high compared to females among HBV patients ,The reason may be attributed to the fact that males in Pakistan have a higher social mobility and freedom, especially in rural areas as compared to females and also male may go to war get hurt and receive urgent blood may be contaminated with HCV, Thus they have a greater chance of contracting the infection.…”

Section: Discussionmentioning

confidence: 75%

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Determination the sero prevalence of HCV among HBV Sudanese patients

Mohammed¹

2022

SPR

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Background: Hepatitis B virus (HBV) infection is a serious public health problem in sub-Saharan Africa. The study aimed to determine the sero prevalence of HCV among HBV patients. Methods: This was a cross-sectional study conducted at Military Hospital-Omdurman. Data including socio-demographical information, age, residence, gender, tribes) also history of hospitalization and blood transfusion, were collected using a structured questionnaire. Blood specimen were collected for detection of antibodies to hepatitis C virus using indirect-Elisa method ,Ethical clearance and informed consent were obtained prior to the enrolment in the study. Data were analyzed using the SPSS program. Results: Elisa test showed that only 4% of patients in this study showed positive result. Most of participants (60%) aged between 30-40 years, followed by 30% between 40-50 years, 10% between 20-30 years of age, 30% of patients were hospitalized while 70% were not hospitalized. Conclusions: Low percentage of HBV patients showed positive ELISA test result of HCV. Severe acute hepatitis B was more frequent in the HBV-HCV co infected group than in the HBV infected group.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 75%

Determination the sero prevalence of HCV among HBV Sudanese patients

Mohammed¹

2022

SPR

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Evaluation of Alpha Fetoprotein Results in Chronic Hepatitis C Patients Who Received Directly Acting Antivral Treatment

Aktaş¹,

Altınkaya²

2021

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Amaç: Kronik hepatit C tanılı hastalarda doğrudan etkili antiviral ilaç tedavisi sonrasında nekroinflamasyonun bir göstergesi olan alfa fetoprotein değerinde meydana gelen değişimi saptamaktır.Gereç ve Yöntemler: Çalışmamızda Ocak 2015 ile Ocak 2020 tarihleri arasında Cumhuriyet Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı Polikliniğinde değerlendirilip kronik hepatit C tanısı ile direkt etkili antiviral tedavi başlanan 294 hastanın verileri retrospektif olarak incelenmiştir. Aldıkları direkt etkili antiviral tedavilerine göre; Sofosbuvir/Ledipasvir ± Ribavirin tedavisi alan hastalar 1. grup (n=114), Paritaprevir + Ritonavir/Ombitasvir ± Dasabuvir ± Ribavirin tedavisi alan hastalar 2. grup (n=180) olarak iki ana grupta değerlendirilmiştir.Bulgular: Hastaların tedavi öncesindeki ortalama alfa fetoprotein değeri 8.25±10.82 ng/ml, tedavi bitimindeki ortalama alfa fetoprotein değeri ise 5.14±10.80 ng/ml olarak saptanmış ve bu değişim istatistiksel olarak anlamlı bulunmuştur (p<0.01). Birinci grupta tedavi bitimindeki alfa fetoprotein değerinde tedavi öncesi değere göre anlamlı düşme gözlenirken (p<0.01), 2. grupta hafif düşme gözlenmiş; ancak bu düşüş istatistiksel olarak anlamlı bulunmamıştır (p=0.175).Sonuç: Çalışmamızda kronik hepatit C tanılı hastalarda güncel antiviral tedaviler ile nekroinflamasyonun bir göstergesi olan alfa fetoprotein değerlerinde gerileme olduğu saptanmış ve direkt etkili antiviral ile tedavi sonrası erken dönemde fibroziste anlamlı iyileşme olduğu görülmüştür.

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Induction of Combination Therapy for the Management of Hepatitis C: An Observational Study

Cited by 2 publications

References 14 publications

Determination the sero prevalence of HCV among HBV Sudanese patients

Determination the sero prevalence of HCV among HBV Sudanese patients

Evaluation of Alpha Fetoprotein Results in Chronic Hepatitis C Patients Who Received Directly Acting Antivral Treatment

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