2005
DOI: 10.1016/j.taap.2004.06.026
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Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity

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Cited by 71 publications
(77 citation statements)
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“…2F). Studies have suggested a role for Cyp1a1 and Cyp1b1 in BaP-mediated bone marrow toxicity (20)(21)(22)(23). Consistent with these studies, gavaging wild-type mice with BaP caused the induction of Cyp1a1, Cyp1a2, and Cyp1b1 mRNAs (Fig.…”
Section: Resultssupporting
confidence: 77%
“…2F). Studies have suggested a role for Cyp1a1 and Cyp1b1 in BaP-mediated bone marrow toxicity (20)(21)(22)(23). Consistent with these studies, gavaging wild-type mice with BaP caused the induction of Cyp1a1, Cyp1a2, and Cyp1b1 mRNAs (Fig.…”
Section: Resultssupporting
confidence: 77%
“…We have previously shown that Cyp1b1 deletion does not affect the blood levels of DMBA or DMBA 3,4 dihydrodiol (Halberg et al, 2008) and that BP forms less dihydrodiol epoxide DNA adducts than does DMBA (Galvá n et al, 2005). Although formation of dihydrodiol epoxide adducts in BM depends on Cyp1b1 (Heidel et al, 2000), the levels of BP dihydrodiols isolated from BM were unaffected by Cyp1b1 deletion (Fig.…”
Section: Resultsmentioning
confidence: 74%
“…It is noteworthy that many of these genes are induced by AhR in combination with the Nrf2/antioxidant response mechanism (Yeager et al, 2009). This process may account for our previous finding that BP dihydrodiol epoxide adducts form much less readily in BM than the equivalent DMBA adducts (Galvá n et al, 2005). However, this response is too slow to account for the AhR-mediated protection, which is effective within 6 h.…”
Section: Discussionmentioning
confidence: 94%
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“…Both DMBA and benzo [a]pyrene exert important effects on bone marrow that alter the formation of B cells. The mechanism of pre-B cell bone-marrow suppression appears to be CYP1B1-dependent and may be caused by pre-B cell apoptosis (Heidel et al, 1999;Mann et al, 1999;Heidel et al, 2000;Allan et al, 2003;Galvan et al, 2003Galvan et al, , 2005.…”
Section: (D) Targets Of Pah Toxicity In the Immune System (I)mentioning
confidence: 99%